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Geriatric-oncological Study on Quality of Life and Independence After Radiotherapy

Geriatrisch-Onkologische Studie Zur Lebensqualität Und Selbstständigkeit Nach Radiotherapie Geriatric-oncological Study on Quality of Life and Independence After Radiotherapy

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05187845
Acronym
GOLD-I
Enrollment
20
Registered
2022-01-12
Start date
2021-02-01
Completion date
2022-04-01
Last updated
2022-11-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Age <70, Cancer

Keywords

quality of life after radiotherapy, independence after radiotherapy

Brief summary

Elderly patients \* with multiple comorbidities are underrepresented in most radio-oncology studies. In times of individualized therapy and when weighing up oncological over- or under-therapy, this observational study is a step towards the implementation of established geriatric instruments and concepts in radiation oncology. As part of the initial outpatient consultation on radiotherapy, the quality of life of patients older than 70 years before the start of therapy is assessed using the EORTC QLQ-C30 and ELD14 questionnaires. Furthermore, a geriatric screening is carried out using the G8 questionnaire. The geriatric screening carried out in routine clinical practice with little effort is used to filter out patients with no risk of increased vulnerability - these participants do not require any further examinations.

Detailed description

Vulnerable patients with deficits (G8 score \<15 pts) receive a geriatric assessment (Comprehensive geriatric assessment (CGA)) consisting of abbreviated comprehensive geriatric assessment (aCGA), appetite (Mini Nutritional Assessment (short form = MNA-SF)) at the beginning and end of radiotherapy ), physical functionality (Short physical performance battery) and measurement of hand strength. In addition, these patients receive an individualized inpatient geriatric-oncological complex treatment, which is already implemented analogous to the palliative complex treatment. The patients receive targeted support from trained nursing staff, social services, physiotherapy, nutritional advice, hospital pharmacies and psycho-oncology. At the end of the oncological therapy and for the first aftercare after the end of therapy, the questionnaires on quality of life are filled out again in order to analyze changes. Initially, 20 patients are to be treated in a first phase (feasibility) in this concept of geriatric-oncological complex treatment in order to build up and expand the necessary structures for an interdisciplinary complex treatment and to set parameters for adherence to the therapy concept and maintaining quality of life and independence in the activities of the daily life for this collective of patients. As part of a follow-up study, vulnerable patients are then to be stratified and randomized using these parameters so that a more detailed analysis is possible.

Interventions

None listed

Sponsors

University Hospital Heidelberg
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
75 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Age from 75 years * G8-Screening \<15Pkt * Potentially curative radiotherapy

Exclusion criteria

* no written informed consent * life expectancy\< 6 month

Design outcomes

Primary

MeasureTime frameDescription
Radiation associated changes in the independence in the activities of daily livingupt to 6 month after radiotherapyChanges in the Barthel Index
Compliance to radiotherapy treatmentthrough treatment time of radiotherapy, an average of 6 weeksnumber of Events of premature termination of planned radiotherapy treatment

Secondary

MeasureTime frameDescription
Therapy associated toxicityup to 6 month after radiotherapyChanges in toxicity assesment according to CTC
Analysis of prognostic factors for radiotherapy Treatment successup to 6 month after radiotherapySex

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026