Diabetic Foot
Conditions
Keywords
Diabetic Foot, Amputation, Cohort Study, Predict model
Brief summary
Diabetic foot can lead to adverse consequences such as amputation and death, which seriously endangering the physical and mental health and quality of life for patients. The aim of this study is to assess factors associated with the occurrence of amputation events in the diabetic foot patients based on a retrospective cohort and to construct a prediction model for patients at high amputated risk.
Detailed description
Diabetic foot is one of the major complications observed in patients with diabetes. Diabetic foot can lead to non-traumatic lower-limb amputation (LLA), and is confirmed to be associated with cognitive decline and worsening quality of life. Previous studies indicated that diabetics had a 25% lifetime risk of developing diabetic foot, and 14% to 24% of those require amputation. In patients with poor results of conservative treatment, amputation is the main terminal treatment option to avoid the spread of infection. Amputation in diabetic foot patients may linked to different causes, including inflammatory, infectious and malignant conditions. A retrospective cohort based on Shandong Provincial Qianfoshan Hospital Healthcare Big Data Platform is conducted to evaluate the progression and prognosis of diabetic foot patients. A prediction model will be developed to identify high-risk diabetic foot patients of amputation and provide a scientific basis for personalized clinical care.
Interventions
None listed
Sponsors
Qianfoshan Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of diabetic foot * Hospitalized patients * No history of amputation
Exclusion criteria
* Patients with Bone Neoplasms * Patients with osteomyelitis not caused by diabetes * Patients with amputation caused by severe peripheral vascular disease not caused by diabetes * Traumatic Amputations * Patients in shock on admission * Patients discharged against medical advice
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| All non-traumatic amputate events | through study completion, an average of 2.2 year | The main outcome was any non-traumatic amputation events among patients with diabetic foots including removing all of a limb or extremity (major amputation) or a portion of a limb or extremity (minor amputation). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Composite outcomes of serious adverse | through study completion, an average of 2.2 year | Including amputations, deaths and other adverse outcomes |
| All-cause mortality | through study completion, an average of 2.2 year | All-cause mortality during hospitalization in patients with diabetic foot. |
| Length of stay in hospital | through study completion, an average of 2.2 year | Hospital length of stay for diabetic foot treatment. |
Countries
China
Outcome results
None listed