Hypogonadotropic Hypogonadism
Conditions
Brief summary
The Hypogonadotropic Hypogonadism(HH) could be caused by sellar lesions, sellar surgery or sellar radiotherapy. The incidence of HH after sellar surgery was higher in men than in women, and the therapy of HH was insufficient. Gonadotropin-releasing hormone(GnRH) stimulation test is used to evaluate the function of pituitary-gonadal axis. GnRH can be used to diagnose and treat fertility disorders and other endocrine disorders caused by HH. After a single injection of GnRH, the patients with poor response of luteinizing hormone and follicle stimulating hormone need to take extended provocation test, which is conducive to the formulation of the following treatment. GnRH pump can pulse subcutaneous injection of gonadorelin, which can be used as the extended provocation test.
Interventions
DRUGGonadorelin
GnRH pump pulse subcutaneous injection of gonadorelin in a month
Sponsors
Huashan Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* patients with HH after surgery of the saddle area * sufficient therapy of the hypothalamic-pituitary-adrenal(HPA) and hypothalamic-pituitary-thyroid(HPT) axis
Exclusion criteria
* contradictions to gonadorelin * androgen-dependent prostate cancer * on the therapy of human chorionic gonadotropin(HCG) or testosterone
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| level of luteinizing hormone, follicle stimulating hormone and testosterone | 1 month | after the GnRH pump of gonadorelin, the level of luteinizing hormone, follicle stimulating hormone and testosterone will be measured at 24h, 1, 2, 3 and 4 week |
Countries
China
Contacts
Primary ContactCuiyun Wu
Outcome results
None listed