Bioavailability of Orally Ingested Vitamin C

Investigating the Oral Bioavailability of Vitamin C Administered Using Phosphycell™ Technology - a Phosphatidylcholine-lipid Encapsulation Technology.

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05183880

Acronym

ABBA

Enrollment

Registered

2022-01-11

Start date

2021-11-26

Completion date

2023-11-26

Last updated

2024-05-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

The purpose of this study is to determine if crystalline vitamin C supplementation can acutely increase skeletal muscle vitamin C concentrations and if this can be potentiated by administering vitamin C using Phosphycell™ Technology - a phosphatidylcholine-lipid encapsulation technology.

Interventions

DIETARY_SUPPLEMENTPhosphatidylcholine-lipid encapsulated vitamin C

Ingesting 1000 mg of vitamin C in phosphatidylcholine-lipid encapsulated form

DIETARY_SUPPLEMENTCrystalline vitamin C

Ingesting 1000 mg of vitamin C in crystalline form

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Body mass index (BMI) 18.5 - 30 kg/m2 * Age 18 - 40 * Non-smoker

Exclusion criteria

* Body mass index (BMI) \< 18.5 or \> 30 kg/m2 * Age \< 18 or \> 40 * Smoking * Cardiovascular disease * Hypertension (≥ 140/90 mmHg) * Metabolic disease * Medications known to affect vitamin C metabolism * A known vitamin C deficiency * Less than 2 hours per week of physical activity or following a structured exercise training program. * Routine use of vitamin supplements

Design outcomes

Primary

Measure	Time frame	Description
Skeletal muscle vitamin C concentrations	6 hours after vitamin C ingestion	Skeletal muscle vitamin C concentrations 6 hours after vitamin C ingestion will be measured using HPLC and compared to baseline

Secondary

Measure	Time frame	Description
Blood plasma vitamin C concentrations	24 hours after vitamin C ingestion	Blood plasma vitamin C concentrations will be measured using HPLC during the 24 hour post vitamin C ingestion period
White blood cell vitamin C concentrations	6 hours after vitamin C ingestion	White blood cell vitamin C concentrations will be measured 6 hours after vitamin C ingestion using HPLC and compared to baseline
Cardiovascular function	24 hours after vitamin C ingestion	Cardiovascular function will be measuring using a finger plethysmograph during the 24 hour post vitamin C ingestion period

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026