Explore the Consistency of Drug Sensitivity Between Primary Colorectal Cancer and Liver Metastases
Conditions
Brief summary
Accumulating evidence indicates that patient- derived organoids (PDOs) can predict drug responses in the clinic. Metastasis is the main cause of death in colorectal cancer patients, and the treatment of patients with liver metastasis remains poor. Tumor heterogeneity is the cause of treatment failure. In this study, we aim the investigate the consistency of drug sensitivity for the matched primary and metastatic tumor in patients with liver metastasis.
Interventions
None listed
Sponsors
Changhai Hospital
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Histologically proven colorectal cancer with liver metastasis * Aged between 18 and 70 years * Written informed and signed consent * Accessible to surgery sample of metastasis and primary tumor
Exclusion criteria
* Less than 18 years and older than 70 years * Not able to give informed consent * Not accessible to surgery sample
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The consistency of drug sensitivity | 3 years | To test the consistency of drug sensitivity of primary tumor and its matched liver metastasis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The establishment of PDO | 3 years | To test the rate of PDO derived from primary and matched metastatic colorectal cancer . |
Countries
China
Outcome results
None listed