Femur Fracture
Conditions
Keywords
fragility lateral femoral fractures, bisphosphonates, clodronic acid, bone density
Brief summary
It was conducted a prospective study with a series of 50 patients treated by intramedullary nail using Clodronic acid and Vitamin D (study group including 25 patients) and patients with the same fractures treated with Vitamin D alone (control group including 25 patients). One independent observer performed clinical, biochemical and functional evaluations at T0 (1st day post-surgery) and at T1 (12 months later) Biochemical markers (serum calcium level, serum phosphate level, PTH (parathormone), Vitamin D, serum C-terminal telopeptide), VAS (Visual Analogic Scale) and HHS (Harris Hip Score) score, and femur densitometric views were administered at each evaluation.
Interventions
DRUGClodronic Acid
Osteoporotic fracture treated with surgical and medical therapy
Sponsors
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* femur fractures type 31-A1, A2, (Muller ME, Nazarian S, Kock P et al.); * age 60 - 85 years; * co-operative patients; * Body Mass Index (BMI) \< 30 Kg/m²; * patients treated by intramedullary nailing surgery (PFNA Synthes®); * patients with osteoporosis disease if T-Score\< -2,5;
Exclusion criteria
* patients with heart, kidney, neurological diseases; * patients with metabolic and systemic disease (rheumatoid arthritis, diabetes mellitus); * previous surgery or severe osteoarthritis of lower limbs; * specific drugs treatments such as anticoagulants or psychiatric drugs.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Visual Analogic Scale | Day 1; Month 12 (after surgey) | The Hip Pain was quantified using the Visual Analogic Scale ranging between 0 (no pain) and 10 points (worst imaginable pain). |
Countries
Italy
Outcome results
None listed