Skip to content

Factors Associated With Post-induction Hypotension in iNPH Patient Undergoing VP and LP Shunt

Factors Associated With Post-induction Hypotension in Idiopathic Normal Pressure Hydrocephalus (iNPH) Patient Undergoing Ventriculoperitoneal (VP) and Lumbar Peritoneal (LP) Shunt

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05183061
Enrollment
426
Registered
2022-01-10
Start date
2021-06-01
Completion date
2021-12-20
Last updated
2022-01-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The iNPH Patients Scheduled for VP or LP Shunt Procedures

Brief summary

This study is a retrospective work involving the review of patients who were scheduled for VP or LP shunt in Siriraj Hospital, Mahidol University, Thailand. The sample size calculation was based on the rule of thumbs of the logistic regression comprising 18 risk factors. The incidence of post-induction hypotension according to our institution's pilot study November 2019-January 2020) was 47%. With 10% addition for missing data and other possible reasons, the sample size was 426. The primary objective of the study is to report the factors associated with post-induction hypotension in iNPH patients undergoing VP or LP shunt procedures. Our secondary objective is to determine the incidence of post-induction hypotension in these patients.

Interventions

DRUGEhedrine Norepineprine

No interventions required considering that this was a retrospective study.

Sponsors

Mahidol University
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Elective cases of iNPH scheduled for VP and LP shunt * Patients aged \> 18 years old

Exclusion criteria

* Emergency cases

Design outcomes

Primary

MeasureTime frameDescription
Factors associated with post-induction hypotension in iNPH patients undergoing VP or LP shunt procedures9 monthsRisk factors associated with post-induction hypotension after administration of anesthetic agents

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026