Comparison of Clinical Effect Between Endoscopic and Microscopic Ear Surgery of Cholesteatoma: A Multicenter Retrospective Observational Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05182268

Enrollment

186

Registered

2022-01-10

Start date

2016-11-01

Completion date

2021-03-30

Last updated

2022-01-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endoscopy; Microscopy; Ear Surgery; Cholesteatoma; Clinical Effect

Brief summary

Background: Cholesteatoma is a potentially life-threatening inflammatory lesion that causes hearing loss, ear discharge, and ear pain, and serious complications. For the past several decades, most studies of cholesteatoma have been restricted to microscopic ear surgery. However, a growing body of evidence suggests endoscopic ear surgery is a safe, minimally invasive approach for cholesteatoma management. This thesis aim to investigate and compare the clinical effect between endoscopic and microscopic ear surgery of cholesteatoma. Materials and methods: The retrospective study included 186 patients with cholesteatoma who received endoscopic or microscopic ear surgery from 11 otorhinolaryngology centers between November 2016 and March 2021. Patients were followed-up for at least 1 year. Audiometry improvement, treatment cost, time, graft success rate and recurrence rate were assessed after surgery.

Interventions

PROCEDUREendoscopic ear surgery

a ear surgery via endoscopic

PROCEDUREmicroscopic ear surgery

a ear surgery via microscopic

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

6 Years to 80 Years

Healthy volunteers

Inclusion criteria

* postoperative pathologically were confirmed cholesteatoma with or without mastoid involvement * the extent of disease was confirmed by preoperative HRCT temporal bone * undergoed microscopic and/or endoscopic surgery for cholesteatoma including primary or revision surgery

Exclusion criteria

* were lacking in clinical characteristics * had not preoperative audiometric data * missed the follow-up data * were lacking in surgical times * were microscopic combined endoscopic ear surgery

Design outcomes

Primary

Measure	Time frame	Description
Pure Tone Average(PTA)	at least 1 year	estimate the auditory acuity
Air-Bone Gap(A-B Gap)	at least 1 year	estimate the auditory acuity

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026