Advanced Maternal Age Pregnancy
Conditions
Keywords
Advanced maternal age
Brief summary
A prospective observational study of pregnancy outcomes at advanced maternal age among primigravida which include maternal ,fetal, obstetric and perinatal outcomes
Detailed description
The investigator will have 2 groups of primigravida , the first group will be presented by 50 women aged 35 y or more and the second group will be presented by 50 women aged 20 y to 34 y The first group will be also divided into 2 subgroups : group (1A ) aged 35 y to 40 y and group (1B) aged above 40 y The investigator will compare the outcomes between the two group , also comparing the outcomes between women with spontaneous pregnancy and those using ART ( Assisted Reproductive Technology ) The participants will undergo routine investigations at the first antenatal visit and a monthly ultrasound examination until delivery The participants will be screened for gestational diabetes mellitus using oral glucose tolerance test between 24 :34 weeks of pregnancy The participants will be screened for gestational hypertension after 20 weeks of pregnancy Obstetric outcomes will be recorded regarding pregnancy induced hypertension, gestational diabetes mellitus , anemia, antepartum hemorrhage, obstetric shock and intrapartum hemorrhage Maternal outcomes will be recorded regarding mode of delivery ,time of delivery ,preterm labor ,obstructed labor and prolonged labor Fetal outcomes will be recorded regarding congenital malformation ,intra uterine growth retardation ,intra uterine fetal death and still birth Perinatal outcomes will be recorded regarded birth weight ,birth asphyxia , neonatal hypoglycemia ,hyperbilirubinemia and ICU admission
Interventions
None listed
Sponsors
Mansoura University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* all primigravida women aged 20 to 34 years in control group and aged 35years or more in case group who seeking for antenatal care in mansoura university hospital and who accept study protocol
Exclusion criteria
* multipara * women aged less than 20 years * women with any medical disorder ( anti phospholipid syndrome , chronic hypertension ,Diabetes, autoimmune disease and thrombosis embolic disease )
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparing the Neonatal outcomes of pregnancy between the young and the elderly group | Between June 2021 to June 2022 and may be extended if needed | Include: * APGAR score system. * Neonatal intensive care unit admission |
| Comparing the Obstetric outcomes as Gestational diabetes mellitus between the young and the elderly group | Between June 2021 to June 2022 and may be extended if needed | Gestational diabetes mellitus by using oral glucose tolerance test between 24 : 28 weeks of pregnancy (in mg/dl), |
| Comparing the Obstetric outcomes as Anemia between the young and the elderly group | Between June 2021 to June 2022 and may be extended if needed | Detecting Anemia by measuring hemoglobin level (in gm/dl). |
| Comparing the Obstetric outcomes as Oligohydramnios or polyhydramnios between the young and the elderly group | Between June 2021 to June 2022 and may be extended if needed | Detected by measuring (amniotic fluid index in cm) by ultrasound. |
| Comparing the Maternal outcomes as Preterm labor between the young and the elderly group | Between June 2021 to June 2022 and may be extended if needed | Preterm labor before 37 w of pregnancy calculated from last menstrual period. |
| Comparing the Fetal outcomes of pregnancy between the young and the elderly group | Between June 2021 to June 2022 and may be extended if needed | Fetal outcomes include: \- Congenital malformation & Intra uterine fetal death (detected by anomaly scan). |
| Comparing the Perinatal outcomes as Birth weight between the young and the elderly group | Between June 2021 to June 2022 and may be extended if needed | Birth weight (in gm). |
| Comparing the Neonatal hypoglycemia between the young and the elderly group | Between June 2021 to June 2022 and may be extended if needed | Detected by measuring neonatal blood glucose level (mg/dl). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparing the Obstetric outcomes as Gestational diabetes mellitus between women with spontaneous pregnancy and those using Assisted Reproductive Technique | Between June 2021 to June 2022 and may be extended if needed | Gestational diabetes mellitus by using oral glucose tolerance test between 24 : 28 weeks of pregnancy (in mg/dl), |
| Comparing the Obstetric outcomes as Anemia between women with spontaneous pregnancy and those using Assisted Reproductive Technique | Between June 2021 to June 2022 and may be extended if needed | Detected by measuring hemoglobin level (in gm/dl). |
| Comparing the Obstetric outcomes as Oligohydramnios or polyhydramnios between women with spontaneous pregnancy and those using Assisted Reproductive Technique | Between June 2021 to June 2022 and may be extended if needed | Oligohydramnios or polyhydramnios by measuring (amniotic fluid index in cm) by ultrasound. |
| Comparing the Maternal outcomes of pregnancy between women with spontaneous pregnancy and those using Assisted Reproductive Technique | Between June 2021 to June 2022 and may be extended if needed | Preterm labor before 37 w of pregnancy calculated from last menstrual period. |
| Comparing the Fetal outcomes of pregnancy between women with spontaneous pregnancy and those using Assisted Reproductive Technique | Between June 2021 to June 2022 and may be extended if needed | Congenital malformation & Intra uterine fetal death (detected by anomaly scan). |
| Comparing the Perinatal outcomes as Birth weight between women with spontaneous pregnancy and those using Assisted Reproductive Technique | Between June 2021 to June 2022 and may be extended if needed | Birth weight (in gm). |
| Comparing the Neonatal hypoglycemia of pregnancy between women with spontaneous pregnancy and those using Assisted Reproductive Technique | Between June 2021 to June 2022 and may be extended if needed | Neonatal hypoglycemia by measure neonatal blood glucose level (mg/dl). |
| Comparing the Neonatal outcomes of pregnancy between women with spontaneous pregnancy and those using Assisted Reproductive Technique | Between June 2021 to June 2022 and may be extended if needed | Include: * APGAR score system. * Neonatal intensive care unit admission |
Countries
Egypt
Outcome results
None listed