Blood Flow Restriction, Multiple Sclerosis, Training Study
Conditions
Keywords
Blood Flow Restriction, Multiple Sclerosis, Exercise
Brief summary
This research is being done to compare the current standard of care for strength training for patients with Multiple Sclerosis to lightweight resistance training with blood flow restriction.
Detailed description
The purpose of this study is to compare the effectiveness of the current Multiple Sclerosis standard of care exercise recommendations to low-load resistance training with blood flow restriction on functional outcomes, strength, muscle size, and neuromuscular control in Multiple Sclerosis patients. This study involves completing 2 training sessions per week for 12 weeks as well as pre- and post-training assessment visits for a total of 29 visits over 14 weeks. All visits will be on UCF's campus with a member of the research team.
Interventions
OTHERBlood Flow Restriction
Resistance training with BFR
OTHERStandard of Care
Resistance Training with no BFR
Sponsors
AdventHealth
University of Central Florida
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Masking description
Participants and Investigators will be aware of treatment groups
Intervention model description
Randomized between group parallel
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Females between the ages of 18 to 55 * Diagnosed with Multiple Sclerosis * Expanded Disability Status Score of 0 to 6.5 * Able to walk 10 meters without assistance * Are willing to come in for all 29 testing visits over 14 weeks
Exclusion criteria
* No other known cardiovascular, pulmonary, metabolic, muscular, and/or coronary heart disease * Multiple Sclerosis relapse in the past 30 days * Are not currently undergoing a rehabilitation protocol * Are not currently seeking medical care for a chronic condition that could limit exercise capacity other than multiple sclerosis * Are not currently pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Functional Outcomes- 10meter | Day 2, Week 4 and 8, Day 28 | determined via changes in 10 meter walk test, measured by how fast (in minutes and seconds) someone can walk 10 meters |
| Change in Functional Outcomes- 6min walk | Day 2, Week 4 and 8, Day 28 | determined via changes in 6 minute walk test, measured by how far (in feet) someone can walk in 6 minutes |
| Change in Functional Outcomes- CST | Day 2, Week 4 and 8, Day 28 | determined via changes in sit-to-stand test, measured by how quickly someone can stand from a seated position |
| Change in Functional Outcomes- 30CST | Day 2, Week 4 and 8, Day 28 | determined via changes in 30 second sit-to-stand, measured by how many times someone can stand from a seated position in 30 seconds |
| Change in Functional Outcomes- MFIS | Day 2, Week 4 and 8, Day 28 | determined via changes in Modified Fatigue Impact Scale Questionnaire, sum score of answers on the questionnaire |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Strength | Day 3, Week 4 and 8, Day 29 | determined via maximal voluntary contractions on the Biodex |
Countries
United States
Outcome results
None listed