Effect of Oat Compounds on Postprandial Glucose Response

Synergistic Effect of Oat Beta-glucans and Oat Polar Lipids on Postprandial Glucose Response

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05177172

Enrollment

Registered

2022-01-04

Start date

2021-12-01

Completion date

2022-01-19

Last updated

2022-01-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Subjects

Keywords

Prevention, food, diabetes type 2, postprandial glucose regulation, appetite, oat, polar lipids, obesity, glucose tolerance

Brief summary

In this project we will investigate synergistic effects of oat polar lipids and beta glucans on postprandial glucose tolerance

Interventions

OTHERHigh beta glucans

higher dose betaglucans

OTHERLow beta glucans

lower dose beta glucans

OTHERLow beta glucans + low polar lipids

low dose betaglucans in a combination with low dose of polar lipids

OTHERPolar lipids

low dose polar lipids

OTHERControl

No beta glucans or polar lipids

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Masking description

Four test products and one reference product (control). Participants are not aware of which product that is served at each visits

Intervention model description

Randomised food study in healthy subjects

Eligibility

Sex/Gender

ALL

Age

20 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy * BMI 20-28 kg/m2 * Diet which follows the Nordic Nutrition Recommendations (non-vegetarian)

Exclusion criteria

* fasting glucose \> 6.1 mmol/L * metabolic diseases * gastrointestinal disease * chronic and/or psychological disease * food allergy * Vegetarian or vegan diets, or other special diets

Design outcomes

Primary

Measure	Time frame	Description
Glucose tolerance	3 hours. Fasting (time =0 minutes), 15 minutes, 30 minutes, 45 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes	Postprandial glucose concentrations (mmol/L). The incremental area under the curve will be calculated and expressed as mmol\*minutes/litre.

Secondary

Measure	Time frame	Description
Subjective appetite variables	3 hours. Fasting (time =0 minutes), 15 minutes, 30 minutes, 45 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes	Postprandial sensation of hunger, satiety, and desire to eat will be determined with a 100 millimeter visual analogue scale (VAS). The left end of the VAS scale represent not at all (e.g. hungry) and right end of the scale represented extremely. One scale for each parameter will be used. The total area under the curve will be calculated, and the results will be expressed as millimeter\*minutes.

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026