ECMELLA vs. ECMO on 30-day Mortality

Treatment With Leftventricular Impella® Micro-axial Pump and Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) During Extracorporeal Cardiopulmonary Resuscitation (eCPR) on Mortality - An International Multicenter Cohort Study

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05175898

Enrollment

Registered

2022-01-04

Start date

2022-02-28

Completion date

2022-11-30

Last updated

2022-01-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Myocardial Infarction, Cardiac Arrest, Cardiogenic Shock, Cardiopulmonary Arrest, Extracorporeal Membrane Oxygenation Complication

Brief summary

This international, multicenter cohort study aims to investigate outcomes after treatment with extracorporeal cardiopulmonary resuscitation (eCPR) during cardiac arrest.

Detailed description

Left ventricular unloading with Impella® micro-axial pump has been shown to improve survival in patients with cardiogenic shock treated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO). This study aims to investigate whether treatment with VA-ECMO and Impella ® (so called ECMELLA) during extracorporeal cardiopulmonary resuscitation is associated with improved outcomes.

Interventions

DEVICEVA-ECMO

Treatment with veno-arterial extracorporeal membrane oxygenation

DEVICEECMELLA

Treatment with veno-arterial extracorporeal membrane oxygenation plus Impella® micro-axial pump.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adult patients * Cardiac arrest * Treatment with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) or ECMELLA (that is VA-ECMO plus left ventricular Impella® micro-axial pump)

Exclusion criteria

* Non-adult patients * No treatment with VA-ECMO or ECMELLA

Design outcomes

Primary

Measure	Time frame	Description
30-day mortality	Mortality within 30 days after cardiac arrest event.	Mortality within 30 days after cardiac arrest event.

Secondary

Measure	Time frame	Description
Hospital length of stay	Through study completion - an average of 1 year.	Number of days between hospital admission and hospital discharge.
Intensive Care Unit (ICU) length of stay	Through study completion - an average of 1 year.	Number of ICU days between ICU admission and ICU discharge.

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026