Skip to content

Comparing Anterior Segment Parameters During Pregnancy and Post-Pregnancy

Comparing Anterior Segment Parameters During Pregnancy and Post-Pregnancy

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05175729
Enrollment
100
Registered
2022-01-04
Start date
2021-12-01
Completion date
2022-08-01
Last updated
2022-08-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy Related

Keywords

Pregnancy, Anterior segment, Corneal Topography, Biometry

Brief summary

The aim of this study is to evaluate anterior segment changes during and after pregnancy, and compare them with non pregnant healty women

Detailed description

Pregnancy is a physiological process in which many systems such as cardiovascular, pulmonary, renal, hematological and visual systems are affected, especially the endocrine system. Many organs, including the eye and orbit, are affected by the physiological interaction between the fetus and the mother. In most pregnant women, these effects are at the physiological level and are temporary; Sometimes it can be pathological and permanent. Hormonal, coagulative and hemodynamic changes are responsible for most of the ocular adaptations. Changes in corneal curvature, sensitivity and thickness are observed during pregnancy. It has been reported that corneal curvature increases with pregnancy, this increase occurs in the last trimester and returns to first trimester values at the end of the breastfeeding period. Although the etiology of this steepening of the cornea has not been clearly clarified, it is thought that it may be due to corneal edema caused by hormonal changes. However, it's not recommended for pregnant women to prescribe contact lenses because their variable keratometric values. A decrease in corneal sensitivity during pregnancy has been detected by esthesiometry in many studies. It decreases especially in the third trimester and returns to normal around the 2nd month after delivery. The corneal thickness measured by pachymeter may increase in pregnant women. some of them had myopic shift. In a study, 83 pregnant women were examined to determine the causes of visual disturbances during pregnancy and postpartum period. Previous studies reported that there was a change in favor of myopia (-0.9±0.3D) during pregnancy and it returned to pre-pregnancy levels in the postpartum period. Unstable refractions were thought to be due to changes in corneal thickness and curvature. As a result, it was stated that the refractive change was temporary and in favor of myopia. It is recommended to wait up to several weeks postpartum before prescribing new eyeglasses \[8\]. There are various reports about IOP in normal pregnant women. In most of these studies, a decrease was found in IOP during pregnancy. In a prospective study, a decrease in IOP was found in the second and third trimesters of pregnancy, and it was shown that this change returned in the first month postpartum. Before planning an anterior segment surgeries such as cataract and refractive surgery, changes in pregnancy should be taken into account and attention should be paid to surgical timing. The aim of this study is to reveal whether there is a change in anterior segment parameters in pregnancy period

Interventions

Measurements of best-corrected visual acuity, refractive error, intraocular pressure, axial length, slit lamp examination of the anterior segment, dilated fundus examination, and anterior segment parameters,corneal topography

Sponsors

Akdeniz University
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Age
19 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

* Ages between 20-40 years * Pregnant women with a gestational age less than 14 weeks in the first examination * Having no systemic disease before and during pregnancy * Having a spherical refractive error of less than 4 diopters, and/or had a cylindrical refractive error of less than 2 diopters

Exclusion criteria

* Having systemic disease, having ocular pathology that may decrease visual acuity * Usage of systemic drugs or topical ocular drops * Usage of exogenous hormones and entered menopause

Design outcomes

Primary

MeasureTime frameDescription
Corneal thickness40 weeksCorneal thickness in mikrometer value
Anterior chamber volume40 weeksAnterior chamber volume in mm3
Anterior chamber depth40 weeksAnterior chamber depth in mm
Anterior chamber angle40 weeksAnterior chamber angle in degree
Lens power40 weeksin diopters
Anterior flat keratometry40 weeksin Diopters
Steep keratometry40 weeksin Diopters
Mean keratometry40 weeksin Diopters
Tonometry40 weeksİntraocular pressure measurement in mmHg
Best corrected visual acuity assessment40 weeksSnellen and logMAR chart
Blood pressure measurement40 weeksSystemic blood pressure
Auto refractometer40 weeksRefractive error measurement in diopter
Axial length40 weeksAxial length in mm

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026