Heart Failure With Preserved Ejection Fraction
Conditions
Keywords
HFpEF, Beta-blocker, echocardiogram, 6MWT
Brief summary
This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.
Detailed description
This is a prospective pilot study to evaluate changes before and 4 weeks(+/- 1 week) after beta-blocker withdrawal in 30 HFpEF patients. The study involves 2 visits that are 4 weeks apart. The first study visit will occur at a standard of care clinic visit and the second visit will be a research visit to fill out questionnaires and perform the limited echocardiogram. No long term follow up beyond the 2nd visit.
Interventions
OTHERbeta blocker discontinuation
beta blocker discontinuation
Sponsors
UConn Health
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Stable HFpEF patients with NYHA Class II-III or elevated BNP ≥100 * N=30 (Target: 30). * Age: 50 \ 80 years. * ECHO evidence of EF ≥50% and Grade 2 or 3 diastolic dysfunction. * Chronic loop diuretic use * Currently on beta-blocker
Exclusion criteria
* Beta blocker was prescribed for treating other cardiac conditions such as atrial fibrillation or coronary artery disease. * Heart rate \> 100 bpm * Recent hospitalization due to HF within 3 months * Non-English speaker
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in KCCQ-23 score | Baseline and after 4 weeks of beta blocker discontinuation | Kansa city cardiomyopathy questionnaire (KCCQ-23)- self-administered, 23-item. questionnaire that quantifies physical limitations, symptoms, self-efficacy, social interference and quality of life. Scores are transformed to a range of 0-100, where higher scores reflect better health status. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in cardiac mechanics by echocardiography | Baseline and after 4 weeks of beta blocker discontinuation | Echocardiographic E/e' ratio |
| Changes in biomarker | Baseline and after 4 weeks of beta blocker discontinuation | changes from baseline in BNP level (pg/mL) after 4 weeks of beta blocker discontinuation |
| 6 minute walk test | Baseline and after 4 weeks of beta blocker discontinuation | The distance (meters) covered over a time of 6 minutes. A greater distance indicates a better exercise capacity. |
Countries
United States
Contacts
Primary ContactKai Chen, MD,PhD
Outcome results
None listed