Nefopam as a Multimodal Analgesia for Thoracic Surgery

Nefopam as a Multimodal Analgesia for Video-assisted Thoracoscopic Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05173337

Enrollment

Registered

2021-12-29

Start date

2021-12-08

Completion date

2022-09-23

Last updated

2023-02-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Cancer

Brief summary

Acute postoperative pain after video-assisted thoracoscopic surgery is very severe. Because pain after thoracic surgery prevents early recovery, and increases postoperative complications, its is important to prevent pain after video-assisted thoracoscopic surgery. In the present study, we will evaluate whether nefopam reduces pain after video-assisted thoracoscopic surgery.

Interventions

DRUGNefopam

Nefopam 20 mg is mixed to 100 mL of normal saline, and is infused intravenously over 15 minutes. 20 mg of nefopam is administered intravenously for two times, after induction and at the end of surgery.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patient scheduled for elective video-assisted thoracoscopic surgery * American Society of Anesthesiologists physical grade I, II, III * patient aged from 18 years old

Exclusion criteria

* history of allergy in nonsteroidal anti-inflammatory drugs, or nefopam * renal insufficiency * liver insufficiency * myocardial infarction * glaucoma * pregnant and lactating women at the time of surgery * patient who did not consent to the use of patient-controlled analgesia

Design outcomes

Primary

Measure	Time frame	Description
Pain after 1 hour of surgery	1 hour after surgery.	Acute postoperative pain will be assessed using numerical rating scale from 0 (no pain) to 10 (worst pain ever).
Pain after 6 hour of surgery	6 hours hours after surgery.	Acute postoperative pain will be assessed using numerical rating scale from 0 (no pain) to 10 (worst pain ever).
Pain after 12 hour of surgery	12 hours after surgery.	Acute postoperative pain will be assessed using numerical rating scale from 0 (no pain) to 10 (worst pain ever).
Pain after 24 hour of surgery	24 hours after surgery.	Acute postoperative pain will be assessed using numerical rating scale from 0 (no pain) to 10 (worst pain ever).

Secondary

Measure	Time frame	Description
Patient-controlled analgesia use	24 hours after surgery	Fentanyl consumption administered thorough the patient-controlled analgesia machine.
Rescue analgesics	24 hours after surgery.	Additional analgesic use during postoperative period.

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 6, 2026