Cystic Fibrosis
Conditions
Keywords
Cystic fibrosis, Exercise program, Lung funcion, Inflammation
Brief summary
Cystic fibrosis (CF) is a genetic disease characterized by abnormal chloride transport in epithelial tissues. Inflammation is a key component contributing to the main alterations induced by the disease. The increase in life expectancy comes with a higher prevalence of CF-related comorbidities, but also with new emerging complications directly related to aging. Physical fitness and exercise practice have been previously associated to survival and better quality of life in patients with cystic fibrosis. Thus, the aim of this study is to assess the effects of a remotely supervised resistance exercise program on lung function, muscle strength, body composition, quality of life and inflammatory markers in adult patients with cystic fibrosis.
Detailed description
This study aims to assess the effects of a remotely supervised resistance exercise program on lung function, muscle strength, body composition, quality of life and inflammatory markers in adult patients with cystic fibrosis.
Interventions
OTHERExercise
Eight-week program of a remotely supervised resistance exercise. Frequency: three times per week. Duration: 60 minutes per session. Training program: warm-up and joint mobility; strength exercises for different muscle groups; and cool down (stretching and breathing exercises).
Sponsors
Universidad Europea de Madrid
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
Evaluators of outcomes will be masked as for the study group of each participant.
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Confirmed clinical and genetic diagnosis for cystic fibrosis; * Age from 16 years.
Exclusion criteria
* Musculoskeletal disorders that do not allow the performance of physical exercise; * Pregnancy; * Absence of registration of clinical required.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in plasmatic levels of interleukins (IL-8 and IL-10) | Baseline and 8 weeks | Change from baseline to 8 weeks |
| Change in peripheral muscle strength. Upper and lower limb muscle strength will be evaluated using the 5 maximum repetition test in specific strength machines. Handgrip strength will be measured with a dynamometer. | Baseline and 8 weeks | Change from baseline to 8 weeks |
| Change in body composition (muscle mass and skeletal mass index - kg/m2) measured through dual-energy x-ray absorptiometry (DEXA) | Baseline and 8 weeks | Change from baseline to 8 weeks |
| Change in plasmatic levels of Klotho | Baseline and 8 weeks | Change from baseline to 8 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in inspiratory muscle strength (MIP) | Baseline and 8 weeks | Change from baseline to 8 weeks |
| Change in functional capacity (30 seconds sit-to-stand test) | Baseline and 8 weeks | Change from baseline to 8 weeks |
| Change in Pulmonary Function (Lung Function) | Baseline and 8 weeks | Change from baseline to 8 weeks |
| Change in quality of life evaluated using the Cystic Fibrosis Questionnaire (CFQ-R +14). Scores range from 0 to 100 with higher scores corresponding to better quality of life. | Baseline and 8 weeks | Change from baseline to 8 weeks |
Countries
Spain
Outcome results
None listed