Fetal Cardiac Disorder
Conditions
Keywords
fetal echocardiography
Brief summary
The study aims to assess the presence of fetal cardiac remodeling and dysfunction in singleton pregnancies conceived by assisted reproductive technology (Biopsied and Non-Biopsied ICSI) as compared with those conceived spontaneously (SC).
Detailed description
For gynecologists, reaching a conclusion about fetal cardiac remodeling and dysfunction in singleton pregnancies conceived by assisted reproductive technology (Biopsied and Non-Biopsied ICSI) or conceived spontaneously (SC) that would influence the clinical decision and best practice. Besides enriching the clinical evidence in fetal cardiac remodeling and dysfunction. For society, the conclusion and recommendation shall maximize the benefits and managing the benefits of the technique used. Moreover, providing more information for fetal cardiac remodeling and dysfunction.
Interventions
None listed
Sponsors
National Research Centre, Egypt
Wael Elbanna Clinic
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 49 Years
Healthy volunteers
Yes
Inclusion criteria
1. Women aged \>18 years 2. Singleton pregnancy 3. Women who are willing and able to attend serial ultrasonographic examinations during the whole pregnancy 4. Women willing to sign an informed consent
Exclusion criteria
1. Multiple pregnancies; more than one fetus 2. Any maternal medical disease, including asthma, chronic hypertension, diabetes mellitus, heart disease, extracardiac anomalies, human immunodeficiency virus or hepatitis infection, immunological disorders, lupus, and thyroid disease 3. Diagnosis of fetal malformations; fetus with a structural or chromosomal anomaly 4. Fetus with Small-for-Gestational-Age (SGA) or intrauterine Growth Restriction (IUGR) (a fetal weight that is below the 10th percentile for gestational age) as determined through an ultrasound. 5. Smokers or drug/alcohol women 6. Inability to understand and provide written informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To assess the presence of fetal cardiac remodeling and dysfunction in singleton pregnancies conceived by assisted reproductive technology (Biopsied and Non-Biopsied ICSI) as compared with those conceived spontaneously (SC) | 2 weeks | Recording the fetal echocardiography data including: 1. Standard fetoplacental data * Estimated fetal weight (g) * Estimated fetal weight (centile) * Uterine artery mean PI * Umbilical artery PI * Middle cerebral artery PI * Cerebroplacental ratio * Ductus venosus PI * Aortic isthmus PI 2. Cardiac morphometric data * Cardiothoracic ratio * Left atrial/heart ratio * Right atrial/heart ratio * Left ventricular sphericity index * Right ventricular sphericity index * Left ventricular free wall thickness (mm) * Septal wall thickness (mm) * Right ventricular free wall thickness (mm) * Myocardial Performance Index (MPI) 3. Systolic function data * Left ejection fraction (%) * Right ejection fraction (%) * MAPSE (mm) * TAPSE (mm) 4. Diastolic function data * Mitral E/A ratio * Tricuspid E/A ratio * Left isovolumic relaxation time (ms) 5. Gestational age at ultrasound examination (weeks) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To describe the baseline and perinatal characteristics in singleton fetuses conceived by assisted reproductive technology (Biopsied and Non-Biopsied ICSI) as compared with those conceived spontaneously (SC | 8 weeks | 1. Maternal characteristics * Age (years) * BMI (kg/m2) * Primiparous 2. Pregnancy complications * Pre-eclampsia * Corticoid exposure * Gestational diabetes 3. Delivery data * GA (weeks) * Cesarean section * Gender * Birth weight (g) * Birth weight centile * SGA (small-for gestational age) 4. Neonatal outcome data * Admission to NICU * Major neonatal morbidity\* |
Countries
Egypt
Contacts
Primary ContactWael El Banna, Consultant
Backup ContactManal Elhinnawi, specialist
Outcome results
None listed