Aortic Surgery, Coagulation Management
Conditions
Keywords
ROTEM, coagulation tests, coagulation disorders, aortic surgery
Brief summary
Comparison of the diagnostic capabilities of rotational thromboelastometry (ROTEM) and standard coagulogram in the detection of disorder and correction of the hemostasis system in the perioperative period in patients who underwent surgical intervention on the aorta under cardiopulmonary bypass and or circulatory arrest.
Detailed description
The patient is monitored in the intensive care unit according to the following scheme: ROTEM (NATEM, INTEM, EXTEM, FIBTEM; with high clotting time (CT) values in INTEM - HEPTEM is done) and a coagulogram (activated coagulation time (ACT), activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen, antithrombin III, platelet aggregation) are done on admission and after 6 hours - with a smooth course of the perioperative period. If it is necessary or the development of disorders in the form of bleeding or thrombosis that require correction, ROTEM and a coagulogram are done, treatment is carried out, and after elimination of the causes, ROTEM and a coagulogram are examined in dynamics to assess the effectiveness of the therapy.
Interventions
DEVICEROTEM and standard coagulation tests
ROTEM and standard coagulation tests assessment
Sponsors
Petrovsky National Research Centre of Surgery
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age from 18 to 80 years. * Patients after surgical interventions on the aorta with cardiopulmonary bypass and/or circulatory arrest (operations on the ascending aorta, aortic arch and thoracoabdominal aorta).
Exclusion criteria
* Patients with other cardiac surgery, including isolated endovascular interventions on the aorta.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The coagulation index | an average of during the first day after surgery | Сhanges of the coagulation index |
| Activated coagulation time | an average of during the first day after surgery | Сhanges of the activated coagulation time |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of repeated operations | an average of 24 hours after surgery | Percentage of repeated operations |
| Percentage of multiple organ failure | an average of 24 hours after surgery | Percentage of multiple organ failure |
| Percentage of serious infectious complication | an average of 24 hours after surgery | Percentage of serious infectious complication |
Countries
Russia
Outcome results
None listed