Magnetic Resonance Imaging, Neuronal Activity
Conditions
Keywords
baby cries, pain, brain responses, fmRI, familiarity
Brief summary
Understanding babies' signals is essential to meet their needs. Recent works suggest that crying provides useful information, not only allowing parents to recognize their baby among others (static information), but also to distinguish between mild discomfort and pain cries (dynamic information). The perception of this information by adults involves a parental brain network including brain areas involved in empathy, attention, emotional regulation, motor as well as regions of the limbic system or associated with the reward network.
Detailed description
This network is involved when listening to cries of familiar babies, or pain cries. How do we become specialist of a baby's cries? To date, no functional imaging study has examined the specific brain activations when listening to the cries of a familiar baby in different situations, particularly painful ones.
Interventions
BEHAVIORALinclusion and familiarization
* presentation of the study purpose and the protocol to the volunteer * clinical examination to check inclusion and exclusion criteria * Familiarization with the crying of one assigned baby, by listening to several bath cries from this baby
BEHAVIORALfMRI acquisition and closure
* Second phase of familiarization, listening again to bath cries of their assigned baby. These cries will be different from those listened during the first familiarization phase. * MRI acquisition: after acquisition of the anatomical images (5 min), the subjects will listen to 64 cries divided into 4 functional MRI sessions of 10 minutes each. The cries will be those of their baby or of unknown babies, evoked in a painful (vaccination) or a non-painful (bath) situation, presented in a pseudo-random order. Participants will be asked to assess whether they recognize their baby (yes/no) and whether they recognize a pain cry (yes/no). * debriefing * Protocol ending
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Group with parental experience caring for infants (20 men and 20 women) Group with professional experience in caring for infants (20 women)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
For all volunteers: * Affiliated or entitled to a social security plan * Right-handed by the Edinburgh laterality test * Having given free, informed and written consent to participate in the study * Having given their consent for the communication of the MRI results to their attending physician Group with parental experience caring for infants : * Men or women between 18 and 50 years old * Parent of a child under 2 years old Group with professional experience in caring for infants * Women between 18 and 50 years old * Without dependent children under 2 years of age * People in daily contact with infants in the professional circle (e.g. nurses, pediatricians, midwives, maternity nurses, etc)
Exclusion criteria
* Pregnant women, parturient, nursing mothers or parents * Persons deprived of liberty, hospitalized without consent, hospitalized for purposes other than research * Minors * Adults under legal protection (guardianship) or unable to express their consent * Subjects with contraindications to the MRI examination: use of a pacemaker or an insulin pump, wearing a metallic prothesis, an intracerebral clip or a piercing, claustrophobia, * Taking medication for less than 12 hours, * Neurological, psychiatric or auditory history or deficits. * Anxiety and/or depressive disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| BOLD signal (blood oxygen level-dependent) | during the whole listening session | Measurement of the BOLD signal by fMRI (functional magnetic resonance imaging) in adults during listening to natural cries of a familiar baby and unknown babies, in two painful (vaccination) or non-painful (bath) situations. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| participants'experience at caring for babies | At the inclusion visit | Experience at caring for babies : Yes or No |
| participants' sex | At the inclusion visit | Sex : Male or female |
Countries
France
Outcome results
None listed