Laser Treated Scars and Optical Coherence Tomography (OCT)

Treatment of Surgical Scar With 2940 nm Erbium: Yttrium Aluminum Garnet (YAG) Laser Examined Under Optical Coherence Tomography

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05166395

Enrollment

Registered

2021-12-21

Start date

2024-05-01

Completion date

2025-12-01

Last updated

2024-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Scar

Keywords

surgical scar

Brief summary

The purpose of this research study is to learn about the effects of the 2940 nm Erbium: Yttrium-Aluminum-Garnet (Er:YAG) laser on treating surgical scar using optical coherence tomography, a medical imaging device.

Interventions

DEVICEEr:YAG laser

2940 nm Er:YAG laser treatment spread over 3 sessions within 4 weeks on participant's scar on either the head/neck, trunk or extremities.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Adults age 18 years or older 2. Patients should have Fitzpatrick skin types of I-IV 3. Patients should have mild to severe post-surgical scarring located on head and neck 4. Scar lengths of at least 3 cm. 5. Ability to understand and the willingness to sign a written informed consent document

Exclusion criteria

1. The patient should not be receiving any additional systemic, topical, or intralesional treatment of the scars during the study 2. Scar size less than 3 cm in length 3. Pregnant or lactating females 4. Fitzpatrick skin type of V-VI 5. Scleroderma 6. Photosensitivity 7. Botulinum toxin injection, facial laser resurfacing, chemical peels, fillers, or usage of oral retinoid within the last 6 months.

Design outcomes

Primary

Measure	Time frame	Description
POSAS Scar Assessment	Up to 13 weeks	Patient and Observer Scar Assessment Scale (POSAS) has a total score ranging from 6 (normal skin) to 60 (severely scarred skin).
Surgical Scar Blood Flow	Up to 13 weeks	As measured using optical coherence tomography
Surgical Scar Skin Roughness	Up to 13 weeks	As measured using optical coherence tomography
Surgical Scar Collagen Content	Up to 13 weeks	As measured using optical coherence tomography
Surgical Scar Epidermal Thickness	Up to 13 weeks	As measured using optical coherence tomography

Secondary

Measure	Time frame	Description
Incidence of Adverse Events	Up to 13 weeks	Adverse events reported by participant and evaluated by treating physician

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026