Peripheral Artery Disease
Conditions
Keywords
Peripheral Artery Disease, Statin, Electronic alert, Best Practice Advisory
Brief summary
The purpose of this study is to understand how a Best Practice Advisory (BPA) for high-intensity statin therapy in patients with Peripheral Artery Disease impacts prescription rates.
Detailed description
The central hypothesis is that an automated best practice advisory embedded within the electronic medical record (EMR) will improve prescription of high-intensity statins among hospitalized patients with Peripheral Artery Disease (PAD). Aim 1: To assess the impact of an automated best practice advisory, deployed as part of the standard hospital discharge workflow within the electronic medical record, on high-intensity statin prescription among hospitalized patients with PAD. Aim 2: To assess the impact of an automated best practice advisory, deployed as part of the standard hospital discharge workflow within the electronic medical record, on short-term cardiovascular outcomes among hospitalized patients with PAD.
Interventions
Patients in this arm will have a Best Practice Advisory displayed in the Electronic Medical Record (EMR) as part of the discharge order workflow.
Sponsors
Vanderbilt University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Primary hospital diagnosis of PAD defined by ICD/CPT codes * Inpatient status at the adult hospital at Vanderbilt University Medical Center * Not currently prescribed a high-intensity statin (atorvastatin 40-80mg daily or rosuvastatin 20-40mg daily)
Exclusion criteria
* On comfort measures * History of statin allergy or intolerance recorded in the EMR * History of rhabdomyolysis defined by International Classification of Diseases/Current Procedural Terminology (ICD/CPT) codes * History of hepatitis A, B, or C defined by ICD/CPT codes * Pregnant * Aspartate aminotransferase \>120 units/L within 30 days of alert * Alanine aminotransferase \>165 units/L within 30 days of alert * Primary hospital diagnosis of acute myocardial infarction defined by ICD/CPT codes * Primary hospital diagnosis of acute stroke defined by ICD/CPT codes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Frequency of High-Intensity Statin Prescription at discharge | Baseline, upon patient discharge through study completion, average of six months | Frequency will be measured by identifying the number of high-intensity statin prescriptions at discharge |
| Frequency of High-Intensity Statin Prescription at 90 days post-discharge | 90 days post-discharge | Frequency will be measured by identifying the number of high-intensity statin prescriptions at 90 days post-discharge. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Frequency of a Composite of Cardiovascular Events | Baseline, upon patient discharge to 90 days post-discharge through study completion | Frequency will be measured by identifying the number of cardiovascular events including myocardial infarction, coronary revascularization, stroke, lower extremity arterial revascularization, or all-cause mortality. |
Countries
United States
Outcome results
None listed