Hypertension,Essential
Conditions
Keywords
Salt sensitivity, Sodium sensitivity, Salt restriction, Salt-blood test, Dietary intervention, Hypertension
Brief summary
This is a randomized controlled trial with 72 patients with hypertension examining the effects on blood pressure of sodium restriction and whether the blood analysis Salt-blood test is associated to a decrease in blood pressure. Patients will be randomized 2:1 to either sodium restriction or usual diet for 4 weeks. Baseline measures will be done before intervention and outcome measures after the 4 weeks.
Interventions
BEHAVIORALSodium restriction
Participants will be guided in minimizing sodium intake. Guidance will be both oral and written. Bread with low sodium content will be offered to the participants.
Sponsors
Regional Hospital Holstebro
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* BMI ≤ 35 kg/m2 * Essential hypertension * eGFR \> 15 ml/min/1,73m2 * Albumine-to-creatinine-ratio \< 500 mg/g * Safe anticonception if women in childbearing age. * Able to adhere to dietary regimen
Exclusion criteria
* Secondary hypertension * Clinically significant heart failure (NYHA 3-4) * Clinically significant liver disease * Diabetes mellitus (type 1 and 2) * Active cancer (except skin cancer) * Renal transplant * Recent stroke, transcient ischemic attack or myocardial infarction (within 6 months) * Proliferative glomerulonephritis or ANCA-related disease * Continuous immunosuppressant treatment * Pregnancy or lactation * Alcohol abuse * If the investigator finds the participant unfit to complete the project
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in systolic 24-hour blood pressure | Measured before and after 4 weeks' intervention | Difference in systolic blood pressure measured before and after intervention |
Countries
Denmark
Outcome results
None listed