Age-Related Osteoporosis
Conditions
Keywords
Bone mineral density, bone turnover marker, high-impact, odd-impact, resistance exercise, menopause, health promotion
Brief summary
To minimize fracture risk, diverse and varied training of high intensity (multimodal training) is recommended to increase bone strength. However, the effectiveness of different training programmes performed in community settings remain uncertain. The present study aimed to evaluate the feasibility and the effectiveness of 19-week of multimodal training in a local community center in Copenhagen, Denmark. The health promotion initiative had special emphasis on musculoskeletal health in postmenopausal women.
Detailed description
A local community center was offering supervised multimodal training (MMT) to postmenopausal, healthy women twice weekly, and the aim of the present study was to evaluate the feasibility and the musculoskeletal health promoting effects of the training. The evaluation study lasted for 19 weeks, and the average attendance rate of MMT participants had to be \> 1 hour weekly. The primary outcomes were bone mineral density (BMD) assessed by Dual-Energy X-ray Absorptiometry (DXA) scanning and the fasted plasma concentration of bone turnover markers (BTM): N-terminal propeptide of type I procollagen (P1NP) , C-terminal telopeptide of type I collagen (CTX), Osteocalcin), while secondary outcomes were body composition variables, dynamic postural balance and functional muscle strength. To test within- and between-group differences in the pre and post outcomes the training group (MMT) was compared with a sedentary control group (CON). Every participant was fully informed before giving her written informed consent to the procedures and potential discomfort associated with the study. The study was conducted in accordance with the Declaration of Helsinki and approved by the local ethics committee of the Capital Region of Denmark, H-18044190.
Interventions
BEHAVIORALmultimodal training (MMT)
Supervised multimodal exercise training (MMT) performed 1-2 hours weekly for 19 weeks
Sponsors
University of Copenhagen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
Healthy, sedentary postmenopausal women aged below 70 years were eligible to participate in the present study. Inclusion criteria were: * non-smoker * body mass index (BMI) \<30 kg/m2. Exclusion criteria were: * T-score \< -3 SD in the lumbar spine or hip * high BMD in relation to age (Z-score \> 1.5 SD) * use of hormone therapy, medical treatment, or supplements that affect bone metabolism * previous or current medical condition affecting bone health * engagement in regular and systematic weight-bearing training or strength training during the preceding two years. Initially, twenty women were recruited to the training via an online advertisement and a local newspaper, but only 19 showed up for pre-testing. After a medical examination, one participant was excluded due to low BMD (T-score \< -3 SD), and two were excluded due to high BMI (≥30 kg/m2).
Eligibility
Sex/Gender
FEMALE
Age
No minimum to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* past menopause * non-smoking * BMI \<30 kg/m2
Exclusion criteria
* T-score \< -3 SD in the lumbar spine or hip * Z-score \> 1.5 SD) * use of hormone therapy, medical treatment or supplements that affect bone metabolism * previous or current medical condition affecting bone health * engagement in regular and systemic weight-bearing training or strength training during the preceding two years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Whole-body and regional BMD | 19 weeks | bone mineral density (g/cm2) |
| Osteocalcin | 3 weeks and 19 weeks | Concentration of Osteocalcin in plasma in fasted state (µg/l) |
| P1NP | 3 weeks and 19 weeks | Concentration of P1NP in plasma in fasted state (µg/l) |
| CTX | 3 weeks and 19 weeks | Concentration of CTX in plasma in fasted state (ng/l) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Total fat mass | 19 weeks | kg |
| Total lean body mass (LBM) | 19 weeks | kg |
| Body fat percentage | 19 weeks | Body fat percentage (%) |
| dynamic balance | 19 weeks | time to fulfill a four-square-balance test (sec) |
| dynamic muscle strength | 19 weeks | Jump-and-reach-test (cm) |
| Whole-body bone mineral content (BMC) | 19 weeks | g |
| Visceral adipose tissue (VAT) | 19 weeks | Volume (m3) |
| Body weight | 19 weeks | kg |
| BMI | 19 weeks | kg/m2 |
Countries
Denmark
Outcome results
None listed