Prospective Athlete's Heart Study

Prospective Athlete's Heart Study: Long-term Assessment of the Determinants of Cardiac Remodelling and Its Clinical Consequences in Endurance Athletes

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05164328

Acronym

Pro@Heart

Enrollment

450

Registered

2021-12-20

Start date

2015-06-23

Completion date

2040-06-23

Last updated

2021-12-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Athlete Heart

Keywords

Athlete, Atrial fibrillation, Arrhythmias, Cardiac remodelling, Cardiomyopathy, Genetics

Brief summary

The Pro@Heart (Prospective Athlete's Heart) study is an international multicentre long-term prospective trial. The primary objective of the Pro@Heart study is to investigate the impact of training load (i.e. accurately evaluated in term of type, frequency, duration and intensity) and genotype on the variability of structural, functional and electrical exercise induced cardiac remodeling (EICR) in young competitive endurance athletes. The second objective is to determine how EICR, training load and genotype are associated with physical performance, health benefits and cardiac pathology (e.g. exercise-related cardiomyopathies and arrhythmias) during follow-up over several decades.

Interventions

OTHERNo intervention

No intervention

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

14 Years to 23 Years

Healthy volunteers

Yes

Inclusion criteria

1. Males and females aged 14-23 years old 2. Athletes competing in endurance sports at national or international level for at least 2 years. Sports include: 1. Triathlon 2. Cycling 3. Distance running (≥ 1500 meters) 4. Rowing 5. Swimming 3. Non athletes engaged in \< 3 hours per week of physical activity

Exclusion criteria

1. Medical history of cardiovascular disease 2. Current smoker of past history of smoking 3. Diabetes mellitus

Design outcomes

Primary

Measure	Time frame	Description
Genotype	Baseline	Rare and common variants in cardiomyopathy associated genes
Training load	Baseline to 20 years	Duration and intensity of training
Atrial fibrillation	Baseline to 20 years	—
Ventricular arrhythmias	Baseline to 20 years	Ventricular ectopic beats, non-sustained and sustained ventricular tachycardia

Countries

Australia, Belgium

Contacts

Primary ContactGuido Claessen, Prof. Dr.

guido.claessen@uzleuven.be

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 12, 2026