Moyamoya
Conditions
Brief summary
Near infrared spectroscpy is a validated method of evaluating cerebral blood flow. The aim in this pilot study to explore its use in children with moyamoya disease.
Detailed description
Moyamoya disease is a cerebrovascular condition in which there is chronic brain hypoperfusion. As surgery can possibly augment brain blood flow, a method for evalutaing cerebrovascualr reserve would be helpful in selecting patients for intervention. Near infrared spectroscopy (NIRS) is a validated non-invasive method of evaluating cerebral blood flow. We aim to investigate the feasibility and tolerability of using NIRS haemodynamic reserve in children with moyamoya and controls by evaluating cerebral blood flow in the baseline state and after breath-holding. Feasibility will be assessed by how many successful studies are carried out. Tolerability will be assessed by asking children some simple questions about their experience.
Interventions
DEVICEnear infrared spectroscopy
evaluate cerebral blood flow with and without breatholding
Sponsors
Great Ormond Street Hospital for Children NHS Foundation Trust
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
patients and controls
Eligibility
Sex/Gender
ALL
Age
6 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
Patients with moyamoya and unaffected healthy controls -
Exclusion criteria
age \<6 \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of NIRS studies that can be completed in moyamoya patients | 2years | how many studies can be completed |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Patient questionnaire to evaluate children's experience of NIRS in moyamoya | 2years | ask children re their experience |
Countries
United Kingdom
Outcome results
None listed