Temporal Lobe Epilepsy
Conditions
Keywords
Closed loop auditory stimulus, sleep, memory
Brief summary
This is a single-centre pilot study of a non-invasive auditory stimulation during sleep in participants with temporal lobe epilepsy.
Detailed description
The primary objectives will be to pilot the use of home-based auditory stimulation during sleep in 10-20 participants with temporal lobe epilepsy using wireless devices.
Interventions
DEVICEClosed loop auditory stimulus
50ms of low volume pink noise delivered during slow wave sleep
Sponsors
Cardiff and Vale University Health Board
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Masking description
auditory stimulus was played at 0 or 50 decibels during sleep
Intervention model description
Within subject comparison of stimulus and sham sessions
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
1. Participant is willing and able to give informed consent 2. Participant diagnosed with temporal lobe epilepsy 3. Will have had fewer than three generalized tonic clonic seizures per month in the last three months 4. Will be taking 3 or fewer anti-seizure medications. 5. Will have access to a computer or cellphone with an internet connection
Exclusion criteria
1. Abnormal hearing that cannot be corrected to normal overnight. 2. Abnormal vision that cannot be corrected to normal during the day. 3. Unwilling to abstain from caffeine, alcohol, daytime naps and extreme physical exercise in the 12 hours prior to the study. 4. Cannot read English 5. Engaged in night work in the previous 2 months 6. Any history of seizures triggered by music or sounds 7. Travelled across more than 2 time zones in the last 2 months 8. Prescribed/taking sleeping tablets other than clobazam 9. Cannabis use \>4 joints/day.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in EEG waveform amplitude | 5 seconds after stimulus | Does the acoustic sound delivery alter EEG waveform amplitude of slow wave sleep |
| Change in Serial Reaction Time Task memory test | Baseline and following day | Does the delivery of acoustic sounds alter post-sleep preformance on the above task |
| Change in Paired Associates Learning memory test | Baseline and following day | Does the delivery of acoustic sounds alter post-sleep preformance on the above task |
Countries
United Kingdom
Outcome results
None listed