Atrial Arrhythmia, Atrial Fibrillation and Flutter, Atrial Fibrillation Recurrent
Conditions
Keywords
impedance spectroscopy, phase angle, impedance magnitude, Electroanatomical mapping
Brief summary
Precise identification of the atrial fibrosis is essential for successful catheter ablation of atrial arrhythmias in patients with atrial fibrillation. Voltage mapping of endocardial electrograms is currently used to delineate the anatomical substrate, but this is influenced by the direction of the activation wave front and is limited by the patient-specific thresholds. Mapping of local myocardial electrical impedance may overcome these limitations.
Detailed description
Clinical series: Patients with atrial arrythmias undergoing catheter ablation of these will be submitted to mapping of both voltage and tissue impedance. Likewise, the accuracy of the two maps identifying the extent of the substrate will be assesssed by gadolinium imaging. The impedance system is already constructed and certified for clinical research use.
Interventions
DEVICEcardioz mapping
Patients will be submitted to mapping of both voltage and tissue impedance.
Sponsors
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Age between 18 and 85 years. * That they understand and sign the informed consent. * That they do not present any contraindication.- Pass the exploration and tests prior to bioimpedance measurements.
Exclusion criteria
* Age outside the range described in the inclusion criteria. * Subjects who present any type of complication during the procedure. * Pregnancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparative detection of atrial scar by voltage mapping | 30 minutes | Voltage will be measured at different sites of the atrial scar and healthy tissue. |
| Comparative detection of atrial scar by impedance mapping | 30 minutes | Myocardial local impedance spectroscopy will be measured at different sites of the atrial scar and healthy tissue. |
| Comparative detection of atrial scar by gadolinium enhanced MR imaging | 30 minutes | Intensity of gadolinium will be measured at different sites of the infarct scar and healthy tissue |
Countries
Spain
Contacts
Primary ContactJose M Guerra, MD, PhD
Backup ContactGerard Amorós, MSc, PhD
Outcome results
None listed