Elder, Renal Function Abnormal
Conditions
Keywords
Renal functional reserve, CKD progression, Elderly
Brief summary
This study investigates renal functional reserve in elderly.
Detailed description
The prevalence of CKD in elder is high as age has been a variable in eGFR equation. eGFR by calculation always declines in parallel with age. The assumption that a persistent over 3 months of eGFR less than 60 mL/min/1.73m2 define CKD with risk of progression and need refer to nephrologist may not necessary true in aging population. We study renal functional reserve in elderly population who risk of CKD progression and ESRD is the highest prevalence in human life cycle and explore whether renal functional reserve can be used as ad additional marker of CKD progression in elderly.
Interventions
None listed
Sponsors
Chulalongkorn University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient age \> 60 years at screening * Patient willing to participate in the study and can provide inform consent * Patient have residual kidney function ≤ 90 ml/min/1.73m2 by CKD-EPI equation
Exclusion criteria
* Patient active smoking * Patient have Charlson comorbidity index \> ..... * Patient active cancer * Patient contraindications for blood collection * Patients with a history of hypersensitivity to cimetidine or amino acid IV solution
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of renal functional reserve per 12 months (mL/min) | 12 months | Renal functional reserve defined as the difference between baseline creatinine clearance and creatinine clearance achieved under stimulation with amino acid infusion. |
Countries
Thailand
Outcome results
None listed