Cerebral Oxygenation in Full-term Neonates
Conditions
Brief summary
The aim of the study was to assess the values of cerebral oxygenation in full-term neonates in the first 10 minutes of life and to compare these values between neonates delivered by normal vaginal delivery and those delivered by elective cesarean section.
Interventions
DEVICENear-infrared spectroscopy
Near-infrared spectroscopy (NIRS) offers the non-invasive continuous monitoring of cerebral oxygenation and perfusion. Cerebral regional oxygen (crSO2) measured via NIRS represents a mixed tissue saturation value, thus enabling information on the balance of cerebral oxygen delivery and oxygen consumption.
Sponsors
Marwa Mohamed Farag
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
0 Minutes to 10 Minutes
Healthy volunteers
Yes
Inclusion criteria
* Gestational age ≥38 weeks, without any medical support and normal pregnancy development.
Exclusion criteria
* Newborns with gestational age \<38 weeks. * Newborns with intrauterine growth restriction. * Evidence of perinatal depression (hypoxic ischemic encephalopathy). * The need for respiratory support or oxygen therapy in the first 10 minutes of life. * Suspected or known brain malformations or congenital cyanotic heart disease. * Birth complications (e.g. vacuum extraction or forceps application). * Newborn delivered through cesarean section with previous attempts of normal vaginal delivery.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cerebral regional oxygen saturation monitoring (crSO2) | the first 10 minutes of life | Measurements was done by using Near infrared spectroscopy (INVOSTM 5100C Cerebral/ Somatic Oximeter Monitor; Covidien) by placing a neonatal brain sensor on the left frontoparietal area of the newborn's head. |
| Peripheral oxygen saturation monitoring (SpO2) | the first 10 minutes of life | Oxygen saturation was measured using pulse oximeter (Masimo or Nellcor) by applying a preductal pulseoximetry sensor to the right wrist. |
| Blood gas analysis | up to 10 minutes of life | It was performed from umbilical cord blood. All newborns will be clinically observed and evaluated during this period by a neonatologist, and clinical status will be assessed by Apgar score. The Apgar score is based on a total score of 1 to 10. The higher the score, the better the baby is doing after birth. A score of 7, 8, or 9 is normal and is a sign that the newborn is in good health. |
| Fractional tissue oxygen extraction (FTOE) | up to 10 minutes of life | After measuring peripheral oxygen saturation (SpO2) and cerebral regional oxygen saturation (crSO2). For evaluation of the balance of oxygen delivery and oxygen consumption, calculation of the fractional tissue oxygen extraction can be done using the following equation: FTOE=(SpO2-crSO2)/SpO2 |
Countries
Egypt
Outcome results
None listed