Propofol Overdose of Undetermined Intent
Conditions
Brief summary
Propofol is one of the most commonly used anesthetics in the world. However, the dose-response of propofol was remarkable variety. Herein, this study aims to investigate the possible association of gene polymorphism and propofol susceptibility, and to research more precise infusion model of this drug.
Detailed description
Patients undergoing gastrointestinal endoscopy will be recruited. Anesthesia is induced with propofol via TCI at 1.5µg/ml, and increases 0.5µg/ml for every 3min until OAA/S score 0. During this period, OAA/S score will be evaluated every 1min until OAA/S score 0. At this moment, the blood concentration of propofol, the doses of propofol, the onset time and BIS are recorded, and blood sample for gene polymorphism detection were required.
Interventions
DRUGPropofol
anesthesia induction is initiated with intravenous infusion propofol at 1.5µg/ml, and increased 0.5µg/ml every 3min until OAA/S score 0.
Sponsors
West China Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. patients who undergoing gastrointestinal endoscopy with anesthesia 2. age ≥18 years
Exclusion criteria
1. hepatic or kidney function injured; 2. received hypnotic sedative drug regularly; 3. Pregnancy, excessive drinking, or current smoker; 4. be allergic to propofol 5. patients who with difficulty communication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| gene polymorphism of propofol susceptibility | from anesthesia induction to the end of the gastrointestinal endoscopy | combination of the blood concentration of propofol (ng/ml) with the onset time(min) at OAA/S score of 0 to demonstrate propofol susceptibility, the gene polymorphism of propofol susceptibility will be detected with the blood sample of subjects. |
Countries
China
Outcome results
None listed