Environment, Exposure, Health Behavior
Conditions
Brief summary
ATHLETE will set up a prospective Europe-wide exposome cohort covering the first 2 decades of the life course, which will integrate data on the external, chemical, physical,behavioral, and social domains of the exposome, as well as on health outcomes and biological omics responses, from preconception until adolescence. As part of ATHLETE, the investigators will follow up a unique existing exposome cohort into adolescence (the HELIX Subcohort).
Interventions
OTHERHELIX's follow-up
* Visit 1 (Day 0): clinical examination (anthropometry, bioimpedance, blood pressure,spirometry), neurodevelopment computer testing, questionnaires (Physical activity,diet, psychological distress, tobacco exposure, pubertal development, sleeping patterns, light exposure before going to sleep, outdoor environment (green spaces, noise), address history, home environment, socio-economic status, noise, psychological distress, medical history, medication use) 7 consecutive days (minimum) of personal exposure monitoring including wearing an actigraph, a Smartphone (GPS data), carrying a NO2 diffusion tube, collection of hair, stool, urines (2 urines during 6 consecutive days) and filling a sleep and physical activity diary * Visit 2 (Day 8): blood collection early in the morning and collection of all the 7- days personal monitoring material, and stools and urines samples.
Sponsors
Poitiers University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
16 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
For the adolescent : * Subject of the EDEN cohort included in the Helix cohort in 2014-2015 in Poitiers (16-19 years old) * Subject benefiting from a Social Security scheme or benefiting through a third party For the person legally responsible : * The legal guardian, if possible the mother, of the adolescent included in Athlete ; * Subject benefiting from a Social Security scheme or benefiting through a third person; * Free subject, without tutorship or guardianship or subordination.
Exclusion criteria
* Concomitant participation in another clinical research study. * Persons not benefiting from a Social Security scheme or not benefiting through a third party. * Adolescents who are incapable or who do not give their consent to follow the study procedures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Urinary biomarkers exposure | One week | Measure of phtalates, phenols, pesticides, (organophosphorus pesticides, metabolites of pyrethroids, 2,4-dichlorophenoxyacid, boscalid, imazalil), cotinine, glycol ethers, polycyclic aromatic hydrocarbon, creatinine, exogenous metabolomics, in a weekly pool of urine collection |
Countries
France
Outcome results
None listed