Mucopolysaccharidosis (MPS)
Conditions
Brief summary
The main aims of the study are to learn about the percentage of mucopolysaccharidosis type II (MPS II) in adults in Brazil as well as about the diagnosis process. No study medicines will be provided to participants in this study. The data available for participants diagnosed with MPS II in DATASUS (a database of the Informatics Department of Brazilian Health System) will be reviewed. No clinic visits will be required as part of participation in this study.
Interventions
OTHERNo Intervention
This is a non-interventional study.
Sponsors
Takeda
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
All MPS II cases of (International Classification of Diseases, 10th revision \[ICD-10\] E76.1) at any age reported in DATASUS from January 1st, 2008 to September 30th, 2020 will be included.
Exclusion criteria
MPS II cases reported outside this period will be excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants Diagnosed With MPS II | From January 1, 2008 to September 30, 2020 | Number of participants diagnosed with MPS II will be reported based on the retrospective data of participants collected from the database (DATASUS). |
| Number of Participants with Comorbidities Associated with MPS II | From January 1, 2008 to September 30, 2020 | Comorbidities will be like respiratory infections, carpal tunnel syndrome and hernia. Number of participants with comorbidities associated with MPSII will be reported based on the retrospective data of participants collected from the database (DATASUS). |
| Age of MPS II Diagnosis | From January 1, 2008 to September 30, 2020 | Age of MPS II diagnosis will be calculated from the date of birth and date of diagnosis. Retrospective data of participants will be collected from the database (DATASUS). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time Between MPS Diagnosis II and Start of Treatment | From January 1, 2008 to September 30, 2020 | Time between MPS diagnosis II and start of treatment will be reported based on the retrospective data of participants collected from the database (DATASUS). |
| Number of Health Care Professionals Who Diagnosed MPS II | From January 1, 2008 to September 30, 2020 | Number of health care professionals who diagnosed the MPS II will be reported based on the retrospective data of participants collected from the database (DATASUS). |
| Number of Treatments Received Before and After MPS II Diagnosis | From January 1, 2008 to September 30, 2020 | Number of treatments received by participant before and after MPS II diagnosis will be reported based on the retrospective data of participants collected from the database (DATASUS). |
| Number of Health Care Professionals Consulted | From January 1, 2008 to September 30, 2020 | Number of health care professionals consulted before MPS II diagnosis will be reported based on the retrospective data of participants collected from the database (DATASUS). |
| Time to MPS II Diagnoses | From January 1, 2008 to September 30, 2020 | Time between first Unified Health System (a Brazilian Health System) consultation and MPS II diagnosis will be reported based on the retrospective data of participants collected from the database (DATASUS). |
Countries
Brazil
Outcome results
None listed