Intravenous Fluids, Pharmacodynamics, Fluid Therapy, Fluid Responsiveness, Fluid Challenge
Conditions
Keywords
intravenous fluids, pharmacodynamics, fluid therapy, fluid responsiveness, fluid challenge
Brief summary
Human digestive system physiologically ensures the absorption of oral water and hydration of the human body. Water is quickly absorbed by the digestive tract with a peak between 15 and 20 minutes. It has demonstrated that oral water remains the best hydration solution that have an effect on plasma volume expansion and cardiovascular system during exercise. While the cardiovascular effect of fluid expansion by saline serum is well known (venous return, preload and cardiac output), effect of oral water varies in the literature depending on the physiological state of the patient and the clinical state. Thus, the investigators aim to investigate oral water effects on fluid responsiveness, regional blood flow and microcirculatory changes.
Interventions
OTHERsaline intravenous administration
Administration of 500 mL of saline (NaCl 0.9%) administered by the venous route
OTHERoral water
500 ml oral water
Sponsors
Centre Hospitalier Universitaire, Amiens
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteer subject between 18 and 30 years old * patient with a regular sinus rhythm * Echogenic subject. * Fasting of solid and liquid since 8 h * Subject in regular sinus rhythm. * Written consent signed.
Exclusion criteria
* Any known cardiac, renal or endocrine pathology. * Arrhythmia rhythm disorder by atrial fibrillation * Pregnant or nursing woman. * Pathology versus indicating Nacl administration. * Person under tutors or curators or deprived of liberty. * Person not affiliated to a social security scheme.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| number of fluid responders 30 minutes after fluid expansion | 30 minutes after fluid expansion |
Countries
France
Outcome results
None listed