Colorectal Adenoma
Conditions
Brief summary
The study aimed to analyze the risk factors of colorectal advanced adenoma and constructe a model to predict the high-risk individuals of harbouring colorectal advanced adenomas, so as to better identify screening participants and provide an important theoretical basis for the prevention of colorectal cancer.
Detailed description
A large cohort of eligible patients were included in the analysis, and classified into derivation and validation cohorts at a ratio of 7:3. Demographic and clinicopathological characteristics of participants were utilized to develop a prediction model for colorectal advanced polyps. In the derivation cohort, the LASSO regression method was applied to filter variables and multivariate logistic regression analysis was used to identify important predictors.A prediction model was established based on the results of multivariate logistic regression analysis. The predictive performance of the model was evaluated with respect to its discrimination, calibration and clinical usefulness.
Interventions
None listed
Sponsors
The First Affiliated Hospital with Nanjing Medical University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients aged ≥18 and ≤75 years old. Patients with complete data on demography and clinicopathology.
Exclusion criteria
* Patients with a history of inflammatory bowel disease, enterophthisis, familial adenomatous polyposis, P-J syndrome and intestinal lymphoma. Patients with a previous history of colorectal neoplasm. Patients with a history of severe systemic diseases. Lack of complete clinical data for analysis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Demographic characteristics of patients with colorectal adenomas checklist | 1 year | Age (years), sex (man/woman), family history of colorectal cancer (in first-degree relatives, including parents and siblings), history of smoking (never, past, current), history of alcohol consumption (never, past, current), regular use of non-steroidal anti-inflammatory drugs |
| weight (kilograms) | 1 year | Clinicopathological characteristics of patients with colorectal adenomas |
| height (meters) | 1 year | Clinicopathological characteristics of patients with colorectal adenomas |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The important high-risk factors of colorectal advanced adenoma | 1 year | The important high-risk factors with p value \< 0.05 |
Countries
China
Contacts
Primary ContactHong Zhu, MD
Outcome results
None listed