Detection of Amyloid Deposits in the Wrist by MRI With Mapping and High Resolution Sequences in Systemic Amyloidosis (AMYLOCARP)

Detection of Amyloid Deposits in the Wrist by MRI With Mapping and High Resolution Sequences in Systemic Amyloidosis

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05150353

Acronym

AMYLOCARP

Enrollment

128

Registered

2021-12-09

Start date

2020-01-24

Completion date

2022-04-26

Last updated

2026-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amyloid, Systemic Amyloidosis

Brief summary

This study is based on the hypothesis that MRI could make it possible to non-invasively detect these amyloid deposits at the level of the wrist using parametric sequences known as T1 mapping, in the form of an extension of T1 in the wrists. areas where amyloid deposits are found in the wrist.

Interventions

PROCEDUREMRI

Wrist MRI

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SCREENING

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Patient group: * Woman or man over 18 years old * With ATTR or AL cardiac amyloidosis with or without carpal tunnel. The diagnosis of amyloidosis must be proven by a positive myocardial biopsy or diphosphonate scintigraphy. * Affiliate or beneficiarie of a social security scheme. * Having signed the free and informed consent. Healthy volunteers: * Woman or man over 18 years old * Affiliate or beneficiarie of a social security scheme. * Having signed the free and informed consent.

Exclusion criteria

Patient group: * Patients participating in another clinical study. * Patients suffering from rheumatoid arthritis or other autoimmune disease (vasculitis, lupus, scleroderma, etc.) * Patients with a medical history of wrist surgery (exclude the operated side). * Patients with a contraindication to performing an MRI (pacemaker, etc.) * Pregnant or breastfeeding women. * Protected patients: Adults under guardianship, curatorship or other legal protection, deprived of their liberty by judicial or administrative decision. Healthy volunteer: * Volunteers participating in another clinical study. * Volunteers suffering from rheumatoid arthritis or other autoimmune disease (vasculitis, lupus, scleroderma, etc.) * Pregnant or breastfeeding women. * Volunteer with a contraindication to performing an MRI (pacemaker, etc.) * Protected volunteers: Adults under guardianship, guardianship or other legal protection, deprived of their liberty by judicial or administrative decision.

Design outcomes

Primary

Measure	Time frame
T1 measurement (ms) associated with each of the 5 regions of interest at the wrist	1 day

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 17, 2026