To Evaluate a Linear Positive Correlation Between Plasma HbA1c and Synovial IL-6 in Diabetic Patients
Conditions
Brief summary
Evaluate the correlation between altered glycometabolic status and joint inflammation in diabetic patients with osteoarthritis undergoing knee replacement surgery
Interventions
DIAGNOSTIC_TESTEvaluation of Synovial IL-6 in diabetic patients with gonarthrosis
To evaluate if there is a linear positive correlation between plasma glycated hemoglobin concentration HbA1c and synovial IL-6 in diabetic patients
Sponsors
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
55 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Diabetic patients * Patients with osteoarthritis awaiting knee replacement surgery * Patients awaiting knee replacement surgery * Patients who agree to sign informed consent
Exclusion criteria
* Patients less than 55 years of age. * Patients over 85 years of age. * Patients who are unable to understand and want. * Patients with severe neurological disorders or with severe disabilities. * Rheumatoid arthritis patients * Cancer patients * Patients suffering from chronic inflammatory bowel syndromes (RCU and Crohn's disease) * Patients on immunosuppressive therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To evaluate if there is a linear positive correlation between plasma glycated hemoglobin concentration HbA1c and synovial IL-6 in diabetic patient | 2 day | To evaluate if there is a linear positive correlation between plasma glycated hemoglobin concentration HbA1c and synovial IL-6 in diabetic patient |
Countries
Italy
Contacts
Primary ContactCesare Donarini
Outcome results
None listed