The Breath-2 Trial

Recovery of Carotid Body Function After Full Recovery Neuromuscular Block

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05149872

Enrollment

Registered

2021-12-08

Start date

2022-08-15

Completion date

2023-04-01

Last updated

2025-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peripheral Chemosensitivity

Brief summary

This is a randomized, cross over, experimental trial in which carotid body function will be evaluated in 35 healthy subjects during partial muscle relaxation and after recovery from muscle relaxation

Interventions

OTHERMuscle relaxation

Rocuronium will be used to induce partial paralysis

OTHERReversal

Sugamamdex will be used to reverse muscle relaxation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

\* age \> 18 years

Exclusion criteria

* BMI index \> 30 kg/m2 * Known or suspected neuromuscular disorders impairing neuromuscular function; * Allergies to muscle relaxants, anesthetics or narcotics; * A (family) history of malignant hyperthermia or any other muscle disease; * Any neurological or psychiatric illness (including a history of anxiety). * ASA class 3 or higher * Gastro-oesophageal regurgitation

Design outcomes

Primary

Measure	Time frame	Description
Carotid body function after full recovery of neuromuscular block	40 minutes after full recovery of neuromuscular block	Carotid body function will be determined by measuring acute hypoxic ventilatory response

Secondary

Measure	Time frame	Description
Carotid body function at symptomatic neuromuscular block	5 minutes after stable partial neuromuscular block	Carotid body function will be determined by measuring acute hypoxic ventilatory response
Carotid body function at full recovery of NMB symptoms	0 minutes after full recovery of neuromuscular block symptoms	Carotid body function will be determined by measuring acute hypoxic ventilatory response
Carotid body function after full recovery of neuromuscular block	20 minutes after full recovery of neuromuscular block symptoms	Carotid body function will be determined by measuring acute hypoxic ventilatory response

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026