Endocrine Hypertension
Conditions
Brief summary
Cases of endocrine hypertension or primary hypertension who have signed informed consent will be collected. Patients with endocrine hypertension will be divided into surgical treatment group and drug treatment group according to actual treatment situation. A database will be established for all patients. The investigators will comprehensively evaluate the general conditions, past medical history, metabolic and biochemical indicators, psychological status, cardiovascular risk factors. All the patients will be followed up for 12 months at baseline, 6 months and 12 months. Clinical data and specimen will be collected.
Detailed description
The investigators will collect 100 patients with secretory hypertension and 100 patients with essential hypertension. Patients with endocrine hypertension will be divided into surgical treatment group and drug treatment group according to actual treatment situation. Resected specimens from surgical patients will be used for immunohistochemistry and western blot. A database will be established for all patients to assess their general situation, past medical history, metabolic and biochemical indicators, psychological status, cardiovascular risk factors, etc. The investigators expect to find more accurate screening indicators from blood and urine specimens. All the patients will be followed up for 12 months at baseline, 6 months and 12 months. Blood pressure, degree of atherosclerosis, biochemical markers, hormone levels and cardiac function indicators will be measured at three time points.
Interventions
PROCEDUREStandardized diagnosis and treatment
Patients with endocrine hypertension undergo surgery or medication depending on the cause after completion of standard diagnostic procedures. Patients with primary hypertension receive medication.
Sponsors
Affiliated Hospital of Nantong University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
age≥18 years
Exclusion criteria
1. myocardial infarction 2. congestive heart failure 3. stroke
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The control rate of blood pressure | 12 months | The investigators will compare the proportion of patients with blood pressure below 140/90 mmHg after different treatments. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes of carotid imima-media thickness | 12 months | Carotid ultrasound will be used to observe the changes of carotid intima-media thickness after different treatments. |
Countries
China
Contacts
Primary ContactGu Yunjuan, M.D/Ph.D
Outcome results
None listed