Oxidative Stress
Conditions
Keywords
Aging, Oxidative Stress, Taurine, Nutritional Supplementation, Therapeutic Strategy
Brief summary
Among the strategies that can improve the body's ability to counteract oxidative stress, the use of nutritional antioxidants has been investigated. Taurine is a semi-essential amino acid, also called a nitrogen compound, which has been used as an effective antioxidant due to its ability to neutralize hypochlorous acid, an extremely toxic oxidant produced by leukocytes in the inflammatory process in humans.
Detailed description
Objective: To evaluate the oxidative parameters of women aged 55 to 70 years after 16 weeks of taurine supplementation. Methods: Twenty-four women age 55 to 70 will be randomly assigned to two groups: control group (GC), supplemented with placebo (1.5 g of starch); and taurine group (GTAU), supplemented with taurine (1.5 g), for 16 weeks. Anthropometry, functional capacity test, taurine, and levels of oxidative stress markers will be determined in pre and post intervention plasma samples. Food consumption will be assessed before, during, and after the intervention. The results will be analyzed by an ANOVA two-way repeated measures mixed model, with the Sidak post hoc (p \< 0.05).
Interventions
DIETARY_SUPPLEMENTTaurine
Taurine supplementation in capsules of 500 grams of taurine powder, total dosage: 1.5 gram/day
DIETARY_SUPPLEMENTPlacebo
Placebo supplementation in capsules of 500 grams of starch powder, total dosage: 1.5 gram/day
Sponsors
Fundação de Amparo à Pesquisa do Estado de São Paulo
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Masking description
Supplement capsule packages were labeled as Supplement A and Supplement B and the nutrient (taurine or placebo- starch) was revealed after the end of the intervention.
Intervention model description
Double-blind placebo controlled study
Eligibility
Sex/Gender
FEMALE
Age
55 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Had being aged 55-70 years; * Female; * Post-menopausal; * Sedentary (not practicing physical exercise for at least 6 months).
Exclusion criteria
* Chronic kidney diseases; * Infectious contagious diseases; * Coronary heart disease; * Smokers * Alcoholics.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in blood oxidative stress marker measurement - Superoxide Dismutase (SOD). | sixteen weeks | The superoxide dismutase (SOD) activity in erythrocytes was evaluated by the spectrophotometric method, and were calculated at 16 weeks in comparision to the baseline. |
| Change from baseline in blood oxidative stress marker measurement - Glutathione reductase (GR). | sixteen weeks | Glutathione reductase (GR) activity was determined by the spectrophotometric method at 37 ºC/340nm after the oxidation of NADPH in the presence of oxidized glutathione, and were calculated at 16 weeks in comparision to the baseline. |
| Change from baseline in blood oxidative stress marker measurement - Malondialdehyde (MDA). | sixteen weeks | The malondialdehyde (MDA) were calculated at 16 weeks in comparision to the baseline. |
Countries
Brazil
Outcome results
None listed