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Outcome After Laparoscopic Surgery for Peptic Ulcer Perforation

Whether Peritoneal Irrigation Intra-operatively Effects on the Outcome After Laparoscopic Surgery for Peptic Ulcer Perforation

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05147870
Enrollment
150
Registered
2021-12-07
Start date
2013-01-01
Completion date
2021-08-31
Last updated
2021-12-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intraabdominal Abscess After Procedure, Leakage, Operation Wound; Infection, Pneumonia

Keywords

Laparoscopic surgery, Perforated peptic ulcer, Peritoneal irrigation, Gauze wiping and suction, Intra-abdominal abscess

Brief summary

Despite advances in laparoscopic surgery for perforated peptic ulcer (PPU), intra-abdominal abscess (IAA) is recognized as one of the commonly reported complications with relation to the extent of infectious abdominal contamination. Herein, the investigators report their experience of laparoscopic surgery for PPU with/without peritoneal irrigation and discuss postoperative outcome. The investigators retrospectively examined the electronic medical records of the patients who underwent laparoscopic surgery for perforated peptic ulcer at a single medical center in Taiwan between January 2013 and August 2021. Retrospectively, the investigators would include those patients with clinical diagnosis of PPU who underwent emergent laparoscopic surgery. The patients with previous abdominal surgery, pathologic confirmed malignant ulcer perforation or concomitant ulcer bleeding were excluded. The investigators focused on post-operative complications and outcome after laparoscopic surgery with or without peritoneal irrigation. This information can be important in improving surgical options with respect to risk and potential benefits in this setting.

Interventions

For patients allocated to the irrigation group, peritoneal lavage was performed at the surgeon's discretion based on surgical findings and preference.

PROCEDURESuction only

In the suction only group, one surgical gauze each was placed in the splenophrenic space and Morison's pouch to soak up any remaining purulent fluid followed by turning the patient into the Trendelenburg position for inspection of the lower abdominal cavity. Any interloop adhesions were carefully divided and the gauze-wiping maneuver was used to soak up the residual peritoneal fluid, and all bowel loops were investigated to the root of the mesentery.

Sponsors

Chang Wei-Jung
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes

Inclusion criteria

* The patients with clinical diagnosis of PPU underwent laparoscopic repair surgery.

Exclusion criteria

* The patients received surgery in an open approach or underwent laparoscopy initially but then intraoperatively converted to laparotomy.

Design outcomes

Primary

MeasureTime frameDescription
Short-term outcome with wound infection, pneumonia, leakage, and intraabdominal abscessThrough hospitalization, an average of 8 daysComplication grading used clavien dindo classification

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026