Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome

Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome, With and Without CPAP, During Wakefulness - Impact on Cognitive Functions

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05147649

Acronym

IRM SAOS

Enrollment

Registered

2021-12-07

Start date

2023-03-02

Completion date

2027-07-02

Last updated

2025-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Sleep Apnea Syndrome

Brief summary

The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration. UA collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory loading in normal subjects elicits respiratory-related cortical activity during wakefulness. The objective of this study is to test whether awake OSAS patients would exhibit a similar cortical activity. Whether or not such cortical compensatory mechanisms have cognitive consequences would be also analyze.

Interventions

DIAGNOSTIC_TESTfunctional magnetic resonance imaging

functional magnetic resonance imaging

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

: 1. OSAS patients * severe OSAS with an Apnea-Hypopnea Index (AHI) \> 30/h * without CPAP treatment 2. Non-OSAS patients * absence of OSAS (AHI \< 15/h and absence of excessive daytime sleepiness with Epworth score \<11) Non-inclusion criteria : * \< 18 years old * \>75 years old * left-handed * BMI\> 40 kg/m² * another sleep disorder * central component of sleep apnea syndrome (central apnea index\> 5 / h) * current or past neurological pathology * respiratory pathology (obstructive ventilatory disorder, restrictive ventilatory disorder, hypercapnia) * MRI contraindication (metallic foreign body, claustrophobia, pregnant woman, etc.) * taking drugs that can modify the BOLD signal on MRI (psychotropic drugs, vasodilators, vasoconstrictors, etc.), * uncorrected sensory impairment (vision or hearing) * protected by law.

Exclusion criteria

: * pregnant woman according to the positive beta-hCG test result * left-handed following the laterality questionnaire * MINI results showing: * a current mood episode * a current disorder of the use of psychoactive substances or in the last 6 months (excluding tobacco) * an eating disorder * a diagnosis of bipolar disorder, current or past schizophrenia

Design outcomes

Primary

Measure	Time frame
Premotor cortex activation in OSAS patients without CPAP	Day 0

Countries

France

Contacts

Primary ContactClaire Launois

claunois@chu-reims.fr3 26 78 83 70

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026