MRI & QST Analysis in Trigeminal Neuralgia and Persistent Idiopathic Facial Pain

Assessing Somatosensory System Damage in Trigeminal Neuralgia and Persistent Idiopathic Facial Pain Through Neuroimaging and Quantitative Sensory Testing

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05147454

Enrollment

Registered

2021-12-07

Start date

2021-11-11

Completion date

2024-11-20

Last updated

2026-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Facial Pain

Brief summary

Patients with a definite diagnosis of classical TGN and PIFP will undergo a structured clinical questionnaire and a trigeminal sensory profile using the quantitative sensory testing. Clinical measures and sensory profiles will be correlated with MRI measures.

Detailed description

Patients with a definite diagnosis of classical TGN and PIFP (according to the 2020 ICOP Classification) will undergo a structured clinical questionnaire and a trigeminal sensory profile using the quantitative sensory testing. Clinical measures and sensory profiles will be correlated with the presence and the geometry of neurovascular compression at MRI. Moreover quantitative structural neuroimaging analysis, such as trigeminal root volume, will be performed in each patient and correlated with clinical and QST data.

Interventions

OTHERQuantitative Sensory Testing

Non-invasive assessment of Sensory Profile

Study design

Observational model

CASE_CROSSOVER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Definite diagnosis of Classical or Idiopathic Trigeminal Neuralgia or Persistent Idiopathic Facial Pain according to the latest ICOP 2020 Criteria * Naive to any surgical procedures

Exclusion criteria

* Any major chronic painful or other neurological disease * Diagnosis of Secondary Trigeminal Neuralgia * Diagnosis of other facial pain syndromes * Cognitive disturbances

Design outcomes

Primary

Measure	Time frame	Description
Sensory Profile	Baseline, at the time of visit	Sensory Profile as assessed by Quantitative Sensory Testing

Secondary

Measure	Time frame	Description
Presence of Neurovascular Compression	Baseline, at the time of visit	Presence of Neurovascular Compression defined as absence of any liquor cleft between the trigeminal root and the offending vessel, on dedicated Trigeminal MRI
Trigeminal Root Volume	Baseline, at the time of visit	Trigeminal Root Volume as assessed by specific neuroimaging Software (MIPAV)
Geometry of Neurovascular Compression	Baseline, at the time of visit	Measurement of the polar coordinates beetween the trigeminal root and the offending vessel as assessed by specific neuroimaging Software (MIPAV)

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 9, 2026