Autistic Disorder, Dental Caries, Pit and Fissure Caries
Conditions
Keywords
Dental sealant, Pit and Fissure sealant, Preventive dentistry, Fluoride varnish
Brief summary
The aim of the study is to compare application of sealants together with fluoride varnishes versus only fluoride varnishes in preventing caries lesions development in the occlusal surface of first permanent molars of children with ASDs.
Detailed description
The aim of the study is to evaluate if the application of pit and fissure sealants together with fluoride varnishes is more effective than the application of the only fluoride varnishes in preventing caries lesions development in the occlusal surface of first permanent molars of children with ASDs. Patients with at least 10-year follow-up and ASDs are recruited and allocated to two cohort according to the strategy adopted for prevention of caries in first permanent molars: FA group (only fluoride varnishes) and FA+S group (sealants together with fluoride varnishes). Caries incidence and sealants retention after the follow-up period are recorded. Demographic and clinical characteristics of patients at first dental visit are also recorded (age, level of cooperation, presence of systemic diseases other than ASDs, caries severity) to evaluate if they play a potential protective and/or risk factors for caries development. Logistic and multivariate analysis are run to evaluate caries incidence and retention rate of sealants in first permanent molars over a period of at least 10 years.
Interventions
PROCEDUREFluoride varnish and pit and fissure sealants onto first permanent molars
Quarterly application of fluoride varnish. Application of pit and fissure sealant, and replacements if necessary.
Sponsors
University of Milan
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Years to 14 Years
Healthy volunteers
No
Inclusion criteria
* ASDs * age less than 14 years * written declaration of informed consent signed by parents/guardians
Exclusion criteria
* incomplete clinical records * missing five or more dental check-ups over the follow-up period * oral or dental care provided in sedation or general anesthesia * follow-up less than 15 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Survival rates from dental caries | 15 years | Percentage of first permanent molars free from caries |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Survival rates of pit and fissure sealant | 15 years | Percentage of pit and fissure sealant sound |
| Evaluation of confounders | 15 years | Evaluation if patient's variables at the first dental visit, such as age, number of dental caries, cooperation level, are positively or negatively associated with first permanent molars decay rates overtime. |
Countries
Italy
Outcome results
None listed