Optimization of 99mTc-Sestamibi Activities in SPECT/CT Myocardial Perfusion Imaging

Personalization of 99mTc-Sestamibi Activities in SPECT/CT Myocardial Perfusion Imaging With the Cardiofocal SmartZoom® Collimator

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05146323

Acronym

OSPECT

Enrollment

294

Registered

2021-12-06

Start date

2021-02-11

Completion date

2021-09-24

Last updated

2021-12-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Heart Disease

Keywords

Myocardial SPECT, Sestamibi, SmartZoom, Cardiofocal collimator, Dose optimization

Brief summary

This work suggests a methodology to adapt the injected radionuclide activity to the level of attenuation of each patient. The investigators propose a dose reduction adapted to the patient's weight, with no significant degradation of the image quality, in order to improve patients and staff radioprotection, standardize the image quality for easier clinical interpretation, and lead to radiopharmaceutical saving in the context of myocardial perfusion Imaging.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patient underwent stress-test 99 mTc-Sestamibi SPECT/CT myocardial perfusion Imaging on a Siemens Intevo Bold Anger camera with the cardiofocal SmartZoom® collimator

Exclusion criteria

* None

Design outcomes

Primary

Measure	Time frame	Description
Number of counts	Day 1	Number of counts in the myocardial region of interest

Secondary

Measure	Time frame	Description
Clinical evaluation	Day 1	Medical evaluation of image quality, in order to establish a correlation between the myocardial signal level and the clinical image quality

Countries

France

Outcome results