Endoscopic Sinus Surgery, Fentanyl
Conditions
Keywords
dexamethasone, Levobupivacaine
Brief summary
Chronic sinusitis (CRS) is a high incidence disease characterized by pus, nasal obstruction, olfactory disturbance, headache, and other symptoms, lasting for more than 12 weeks, with severe cases having ocular compression and visual impairment, which can cause cranial, eye, and lung complications. Chronic sinusitis is a high-risk disease.
Detailed description
One of the main concerns about using packing is that the removal is usually very painful and can be very bothersome. This procedure may even result in syncope by the activation of the vasovagal reflex system. There have been a few studies suggesting that nasal packs should not be used because removal from the nose causes serious discomfort and is painful. Many patients who have undergone nasal surgery report that the removal of the pack was the most painful part of the experience. Postoperative pain is an acute inflammatory pain that starts with surgical trauma and ends with tissue healing. It can be harmful to organ systems by initiating inflamma¬tion through different mechanisms, and the alleviation of postoperative pain is considered important for obtaining homeostasis. Pain may initiate atelectasis due to improper coughing, immobilization may cause thromboembolism and catecholamine discharge may induce cardiovascular side effects and undesired changes in neuroendocrine or meta¬bolic function
Interventions
DRUGSaline 0.9%
0.9 NaCl % (Saline) (5 ml) will be applied
0.25 % levobupivacaine (5 ml) will be applied.
DRUGFentanyl
fentanyl plus 0.25 % levobupivacaine (5 ml) will be applied.
DRUGDexamethasone
Dexamethasone plus levobupivacaine (5 ml) will be applied.
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* • ASA physical status I-II patients * scheduled for elective FESS surgery. • Age from 18 to 65 years patients
Exclusion criteria
* • Age\>18 and\<65 years patients, * Previous history of FESS, * Patients with sensitivity to anesthetic agents in the study, * Patients who will do additional septoplasty or turbinate surgery, * Patients with disturbance of blood coagulation, including pro¬thrombin time (PT)/partial thromboplastin time (PTT) prolon¬gation, purpura, and spontaneous bleeding;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| time to first post-operative analgesic request | 24 hours postoperative | when patient require analgesia |
Countries
Egypt
Contacts
Primary ContactGhada Abo Elfadl, MD
Outcome results
None listed