IL-6 Concentration in the Synovial Fluid of Obese Patients is 100% Higher Than the IL-6 Concentration of the Synovial Fluid in Normal Weight Patients
Conditions
Brief summary
Evaluate the concentration of IL-6 in the synovial fluid of obese patients suffering from gonarthrosis during knee arthroplasty surgery
Interventions
DIAGNOSTIC_TESTEvaluation of IL-6 biomarkers in synovial fluid
Evaluation of IL-6 biomarkers in synovial fluid in obese and normal weight patients with gonarthrosis
Sponsors
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
55 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* age between 55 and 85 years inclusive, * Normal weight patients with BMI 18-24.9 included * Obese patients with BMI ≥ 30 * Patients suffering from gonarthrosis awaiting knee arthroplasty surgery * Patients awaiting knee replacement surgery * Patients who agree to sign informed consent
Exclusion criteria
* Patients under 55 years of age. * Patients over 85 years of age * Patients suffering from diabetes mellitus * Patients who are unable to understand * Patients with severe neurological disorders or severe disability * Rheumatoid arthritis patients * Cancer patients * Patients on immunosuppressive therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate whether the IL-6 concentration in the synovial fluid of obese patients is 100% higher than the IL-6 concentration of the synovial fluid in normal weight patients | 1 day |
Countries
Italy
Outcome results
None listed