Analgesia
Conditions
Keywords
analgesia, dexamethasone, paracetamol
Brief summary
Tonsillectomy is one of the most common surgical operations performed on children, and it is frequently linked with an increased risk of complications such as acute discomfort when swallowing and postoperative nausea and vomiting (PONV).The most prevalent causes for postponing discharge home are poorly managed pain and PONV.
Detailed description
Tonsillectomy is one of the most common surgical operations performed on children, and it is frequently linked with an increased risk of complications such as acute discomfort when swallowing and postoperative nausea and vomiting (PONV). The most prevalent causes for postponing discharge home are poorly managed pain and PONV. As a result, these occurrences should be avoided and managed utilizing a multimodal strategy Because of its low cost and adequate safety profile in the treatment of post-tonsillectomy pain, acetaminophen is presently regarded the fundamental analgesic in this situation. Furthermore, acetaminophen has been recommended for use in children, and its pharmacological safety in this age group has been shown. Dexamethasone is another medication that is used to reduce postoperative pain and PONV in various procedures.
Interventions
DRUGparacetamol
patients will receive intravenous paracetamol 30mg/kg (max 90 mg/kg/day)
DRUGDexamethasone
patients will receive dexamethasone 0.5mg/kg IV.
DRUGnormal Saline
patients will receive placebo 10 ml normal saline IV.
Sponsors
Benha University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
3 Years to 16 Years
Healthy volunteers
Yes
Inclusion criteria
* children aged between 3 and 16 years. * All patients are ASA physical status I or II scheduled to undergo a tonsillectomy with or without adenoidectomy using sharp dissection technique.
Exclusion criteria
* psychiatric illness. * cardiac disease. * renal or hepatic impairment. * allergy dexamethasone , paracetamol and opioids.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total opioid consumption at PACU | two hours postoperatively | total amount of opioid that will be taken by the patients postoperatively. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| objective pain score | at 0 minute , 30 minutes ,1 hour and 2 hours at PACU | pain score will be assessed by 4 points pain scale 0=no pain 1 = mild pain 2= moderate pain 3=severe pain |
Countries
Egypt
Outcome results
None listed