Eclampsia, Posterior Reversible Encephalopathy Syndrome, Preeclampsia, Pregnancy Outcomes
Conditions
Brief summary
The purpose of this study is to determine the features of clinical imaging, disease severity and pregnancy outcomes in posterior reversible encephalopathy syndrome with preeclampsia or eclampsia.
Detailed description
The investigators retrospectively collected data (General information, clinical data, biochemical indicators, imaging features, and pregnancy outcome) from pregnant woman diagnosed with PRES with preeclampsia or eclampsia to analyze features of clinical imaging, disease severity and pregnancy outcomes during 2012 to 2021.Then, the investigators grouped all the patients into early onset group and late onset PE group according to gestational weeks to analyze differences of clinical imaging. Finally, the investigators grouped all the patients into good pregnancy outcomes group and poor pregnancy outcomes group according to diagnostic criteria, including the incidence of stillbirth and premature birth, to analyze differences of clinical imaging .
Interventions
DIAGNOSTIC_TESTPRES in PE or E
patients diagnosed with posterior reversible encephalopathy syndrome with preeclampsia or eclampsia
Sponsors
Dunjin Chen
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
16 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
1. patients were diagnosed of PRES with PE or E 2. all patients provided written informed consent
Exclusion criteria
1. patients combined with other neurological disorders 2. patients combined with mental illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| features of clinical imaging | Cranial Imaging was examined immediately at the onset of symptoms, such as s headaches, visual changes, seizures, consciousness impairment, mental disorders, and focal neurological deficits. | The imaging features were described by their location including frontal, parietal, occipital, temporal, cerebellum, basal ganglia, brain stem, deep white matter and callosum, and 1 point was recorded for each location involved. |
| blood pressure(BP) | The BP of patients was obtained immediately at the onset of symptoms. | hypertension：≥140/90mmHg |
| biochemical parameters | Biochemical indicators were collected within 1 week of the hospital stay. | The PRES patients may have a lower level of serum albumin (﹤35g/L) ,and have a higher level of lactic dehydrogenase (﹥380U/L). |
| pregnancy outcomes | The pregnancy outcomes will record immediately when the patients deliver. | The rates of stillbirth and premature birth (gestation less than 37 weeks) in PRES patients. |
Countries
China
Outcome results
None listed