Acute Kidney Injury, Endocarditis
Conditions
Keywords
Endocarditis, Acute kidney injury, Amoxicillin, Cloxacillin
Brief summary
2015 European Society of Cardiology Guidelines have proposed the combination of Ampicillin and Cloxacillin for initial empirical treatment of infective endocarditis in acute severely ill patients (before pathogen identification). Yet this combination has never been studied in clinical trials. High dose penicillin treatments are associated with a risk of nephrotoxicity. The investigator's primary purpose is to describe patients treated with high dose Amoxicillin and Cloxacillin combination and to evaluate its renal tolerance.
Interventions
None listed
Sponsors
University Hospital, Strasbourg, France
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Adult patient (≥18 years old) * Hospitalized at the Strasbourg University Hospital and treated concomitantly with Amoxicillin IV and Cloxacillin IV for ≥48 hours between January 1, 2016 and December 31, 2020. * Patient not having expressed his opposition, after information, to the reuse of his data for scientific research purposes.
Exclusion criteria
* Subject having expressed opposition to participating in the study * Subject under guardianship, curatorship or safeguard of justice
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Description of patients treated with dual IV therapy combining cloxacillin and amoxicillin in high doses at Strasbourg University Hospital | Files analysed retrospectively from January 01, 2016 to December 31, 2020 will be examined] |
Countries
France
Contacts
Primary ContactYvon RUCH, MD
Backup ContactSaïd CHAYER, PhD, HDR
Outcome results
None listed