Charcot-Marie-Tooth Type 1A Neuropathy
Conditions
Keywords
Charcot-Marie-Tooth disease type 1A neuropathy, Fall risk, Walking, Timed Up and Go test, 6-Minutes Walk test
Brief summary
The main objective of this study is to explore the relationship between the onset of fall and the time taken to complete the Timed Up and Go test (TUG) in this CMT1A patient population. The investigators hypothesize that patients with balance disorders and therefore a risk of major fall will require a longer time to perform the Timed Up and Go test. In addition, it seems important to confirm that the severity of the disease has a negative impact on the frequency of balance disorders.
Detailed description
Charcot-Marie Tooth disease is the most frequent and common inherited neuropathy with the various forms and subtypes. The CMT-1A is the most frequent form of the disease and represents more than eighty percent of the all subtypes. In view of different clinical elements (muscular strength deficit, walking and balance disorders, podological impairment), patients with CMT seem to be able to present an increased risk of fall. In 2017 pilot study supports this. More recently, a study by Ramdharry et al. appears to confirm this with a cohort of 252 patients with CMT, 86% of whom have experienced at least one major fall or loss of balance. This increased incidence of falls is also found in children and adolescents with CMT with consequences in terms of injury and management. Systematic screening of the risk of falls in this population is necessary, but no prospective studies on the occurrence of falls and its detection have yet been carried out in this population. A study focusing on this issue in order to standardize the assessment of postural control disorders using a simple test of common clinical practice seems necessary.
Interventions
DIAGNOSTIC_TESTExploratory physiopathology study, including non-invasive functional explorations carried out in patients with Charcot-Marie-Tooth disease type 1A
The data of the gait analysis, posturography and strength analyses as well as the questionnaires' scores will be taken into account in this research. At 6 months and at 1 year, occurrence of a fall will be recorded in order to prospectively monitor this parameter. A final analysis will be carried out at 1 year from the first according to the same methods as the initial assessment.
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
The patients will be recruited in the PMR and neurology departments within the framework of their pathology (current care) and via an older cohort of CMT1A. During a follow-up medical consultation, patients will be informed about the study. If patients express an interest, participants will be listed as a potential attendee. After reflection, patients will be contacted to confirm their participation and an appointment will be set. An assessment will be carried out within the PMR Department of Clermont-Ferrand University Hospital. The doctor will present the protocol in detail to the patients. Upon reading the information form, the doctor will obtain written consent. Clinical information and the results of the various tests will be recorded. Participants will then be compared with each other and over time. Secondly, patients will be contacted by telephone at 6 months to receive any self-reported fall via a standardized questionnaire.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients older than 18 years * Diagnosis of Charcot Marie Tooth disease, type 1A confirmed by molecular biology (duplication 17.p11.2) and by a pathological electromyogram, that is to say with demyelinating impairment (+/- axonal) dependent length * Listening and written French * Strength of the quadriceps superior to 2/5 MMT MRC * Agreement after written information, clear and honest about the purpose of the study, the nature of the tests and their possible side effects or bothersome * Health insurance cover
Exclusion criteria
* Presence of other neurological comorbidity * Presence of coronary artery disease unstabilized * Peripheral neuropathy of other causes: diabetes, monoclonal gammopathy, malignancy, solid cancer, systemic autoimmune disease (lupus, Sjögren's disease, Wegener sarcoidosis ...), infectious disease (viral hepatitis, HIV ...), drugs known to be responsible for iatrogenic neuropathy. * Gait trouble of other origin * Patients unable to give their consent. * Intellectual deficit that does not allow to comply with tests * Patient under guardianship, or protection of justice.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Main explanatory variable: Time to complete the Timed Up and Go test (TUG) (in seconds) | 1 day , 6 months, 12 months | It uses the time that a person takes to rise from a chair, walk three meters, turn around, walk back to the chair, and sit down. Investigators measures an evolution or not at 6 months and 1 years. |
| Main dependent variable: Self-reported occurrence of fall. | 6 months , 12 months | A fall book will be issued to the patient during the first consultation to trace the date, the circumstances of occurrence. Investigators seek to find an improvement or not in the number of falls at 6 months and 1 year. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm). | Day 0 , 12 months | Maximum voluntary isometric strength of the quadriceps muscles will be measured with the CYBEX device. |
| Body Mass Index (Kg/m²). | Day 0 , 12 months | BMI will be calculated (weight in kilograms divided by height in meters squared). |
| : Muscle Strength measured by Medical Research Council (MRC) Scale | Day 0 , 12 months | The muscle scale grades muscle power on a scale of 0 to 5 in relation to the maximum expected for that muscle. The patient's effort is graded on a scale of 0-5: Grade 5: Muscle contracts normally against full resistance and Grade 0: No movement is observed. |
| Weight (Kg). | Day 0 , 12 months | Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations. |
| Sarcopenia risk. | : Day 0 , 12 months | Sarcopenia risk will be evaluated with the SARC-F Questionnaire. |
| Height (cm). | Day 0 , 12 months | Height will be measured with a wall mounted tape measure and according to the ISAK recommendations. |
| Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm). | Day 0 , 12 months | Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the device. |
Countries
France
Outcome results
None listed